Friday, October 30, 2026 · Edition updated 6:00 AM ETFRI, OCT 30 · 6 AM ET editionNext edition in Next --:--:--

What's new, in plain English

Gathered every morning from PubMed, bioRxiv, medRxiv, ClinicalTrials.gov and the FDA. Each item links to its original source.

Now recruiting · ClinicalTrials.gov · Oct 283Staying socially connected

Nursing home residents and nursing students may meet in a planned pairing program

This trial will test a six-week program where nursing home residents and nursing students meet weekly. It will look at joy of life, loneliness, and ageism before and after.

Original title: Intergenerational Interaction Program for Nursing Home Residents and Nursing Students

Opening soon · ClinicalTrials.gov · Oct 284Strength training

Comparing exercise mixes for adults over 50 with prediabetes

This trial plans to compare three exercise mixes with a health education group. It has not started yet, so no results exist.

Original title: Different Aerobic-to-Resistance Training Ratios in Adults Aged 50 Years and Older With Prediabetes

Opening soon · ClinicalTrials.gov · Oct 28

Does how long a dialysis filter is used affect new infections in very sick patients

A trial plans to look at factors that may raise the risk of new infections in very ill patients with kidney injury. It has not started yet, so no results exist.

Original title: Effect of Filter Lifespan in CRRT on New Infections in Critically Ill Patients With AKI

Opening soon · ClinicalTrials.gov · Oct 272Creatine

Testing creatine and HMB with home exercise for muscle loss in Huntington's disease

Researchers plan to compare creatine, HMB, both together, and a placebo, with all groups doing home exercise. The study has not started recruiting, so no results exist yet.

Original title: Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease

Now recruiting · ClinicalTrials.gov · Oct 262Laser resurfacing (CO2 and fractional lasers)

Laser alone versus laser with ultrasound for facial skin aging in women

This is a planned small trial that is still recruiting, and no results have been posted yet. It will compare the two treatments on each side of the face, but it cannot yet tell us which works better.

Tested in 10 women aged 50 to 65 at one clinic in Montreal

Original title: Ultraformer MPT Combined With Fractional CO2 Versus Fractional CO2 Alone for Facial Rejuvenation

Opening soon · ClinicalTrials.gov · Oct 264Strength training

A wearable ankle device to help older adults walk better is being tested

This is a plan for a study that has not started recruiting people yet. It does not show that the device works, because no results have been posted.

Tested in Older adults, not yet enrolled

Original title: Wearable Ankle Power Training (WearAPT) for Enhanced Mobility in Aging

New trial · ClinicalTrials.gov · Oct 26

Selenium levels and muscle loss in kidney dialysis patients

This study looks at whether selenium in the blood is linked to weak muscles and frailty in dialysis patients. It is a registration of a planned study, and it has not posted any results yet.

Original title: Selenium, Sarcopenia, and Frailty in Hemodialysis

New trial · ClinicalTrials.gov · Oct 264Exercise

Can exercise help older adults sleep better and use fewer sleep pills

Researchers plan to test whether a 12-week exercise program helps people over 50 sleep better and take less sleep medicine. This is a planned study, so it does not show any results yet.

Tested in 180 adults aged 50 and older in Taiwan who use sleep medicine long term

Original title: Physical Activity Interventions for Sleep Improvement and Sedative-Hypnotic Reduction in Middle-Aged and Older Adults: Investigating the Role of Sarcopenia

New trial · ClinicalTrials.gov · Oct 264Balance training and preventing falls

Village doctor fall prevention program for older adults in rural China

This trial tested a fall program run by village doctors in rural Chongqing. It was marked completed, but no results have been posted, so we cannot yet tell if it worked.

Tested in 320 older adults in 8 villages

Original title: Village Doctor-Delivered Fall Prevention Program for Older Adults in Rural Chongqing

Opening soon · ClinicalTrials.gov · Oct 26

Does daily functioning and nutrition predict outcomes in older heart attack patients

Researchers plan to check whether everyday abilities and poor nutrition before a heart attack predict later health problems. This is a planned study, so it cannot yet show any results or answers.

Tested in About 270 adults aged 65 and older in two hospitals in Russia

Original title: Prognostic Value of Functional-Nutritional Status in Older Adults With Acute Coronary Syndrome

Opening soon · ClinicalTrials.gov · Oct 25

Studying a gut hormone called FGF-19 in older adults with and without frailty

This study plans to measure how FGF-19 levels change after meals in older adults. It has not started recruiting, and no results have been posted yet.

Original title: PROfiles of FGF-19 Post-prandial Secretion in Older Adults With Frailty and Without Frailty

New trial · ClinicalTrials.gov · Oct 252Ultrasound skin lifting (Ultherapy)

Non-surgical brow lift combining ultrasound, toxin and filler in 36 adults

Researchers tracked adults who had one combined non-surgical brow treatment and measured eyebrow height over a year. The study did not compare this treatment with any other option, so it cannot show it works better.

Tested in 36 adults

Original title: Single-Session Microfocused Ultrasound, AbobotulinumtoxinA and Temporal Hyaluronic Acid Filler for Non-Surgical Brow Lifting

Now recruiting · ClinicalTrials.gov · Oct 254Exercise

Does exercise before colorectal cancer surgery lower complications? A new trial is recruiting

This trial is testing whether strength, endurance, or both kinds of exercise before surgery lower complications. It has not reported results yet, so it cannot yet show if any exercise helps.

Original title: Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery

Now recruiting · ClinicalTrials.gov · Oct 22

Training program for emergency nurses on frailty in older adults

This trial will test whether a training program helps emergency nurses recognize frailty in older adults. It has not reported results, so it cannot yet show whether the training works.

Tested in 144 emergency nurses in 8 public hospitals in Morocco

Original title: Frailty Training for Emergency Nurses: A Cluster RCT in Morocco

Opening soon · ClinicalTrials.gov · Oct 222Creatine

Creatine and walking football for older adults in Madrid: a planned study

This is a planned study that has not started recruiting people yet. It will test whether creatine plus walking football helps muscle and metabolism in older adults.

Original title: Creatine and Muscle Health in Madrid's Walking Footballers.

Opening soon · ClinicalTrials.gov · Oct 224Exercise

Testing two amounts of jump-free plyometric exercise in inactive older adults

This trial will compare a high amount and a low amount of plyometric exercise without jumping, plus a control group. It has not reported results yet, so it does not show whether either amount helps.

Original title: Effects of Different Amounts of Plyometric Exercise Without Jumping in Physically Inactive Older Adults

Opening soon · ClinicalTrials.gov · Oct 224Vaccines for adults

A new shingles vaccine trial for adults aged 40 and up

This is a plan for a study that has not started recruiting people yet. It does not show whether the vaccine works or is safe.

Original title: Immunogenicity and Safety of SYS6052 in the Participants Aged 40 Years and Above

Now recruiting · ClinicalTrials.gov · Oct 22

A study of Alzheimer's disease in older adults in Fujian, China

Researchers plan to follow older adults over time to learn how Alzheimer's disease changes. The study is still recruiting, so no results are available yet.

Original title: Fuzhou Aging Brain Health Initiative

New trial · ClinicalTrials.gov · Oct 212Urolithin A

Testing whether medicines and a skin treatment can lower biological age

This study is a trial that is still signing up people by invitation, and no results have been posted yet. It will test whether treatments can lower measured biological age in skin and blood.

Original title: Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging Clocks

Opening soon · ClinicalTrials.gov · Oct 21

Could new teeth on implants slow biological aging in older adults?

This study plans to track whether fixed implant teeth change biological age over two years. It has not started yet, so it cannot yet show any effect.

Tested in 60 adults aged 50 or older with no natural teeth

Original title: Biological Aging Following Full-Arch Implant-Supported Fixed Rehabilitation in Edentulous Patients

Opening soon · ClinicalTrials.gov · Oct 214Balance training and preventing falls

Testing an exercise and pain education program for falls in older adults with long-term pain

This is a planned small trial, not yet recruiting, so no results exist. It will check if the program is doable, safe, and liked, and gather early clues about effects.

Original title: Multicomponent Exercise and Pain Science Education for Fall Prevention in Older Adults With Chronic Musculoskeletal Pain (MovePainFall)

New trial · ClinicalTrials.gov · Oct 202Air pollution (outdoor and indoor)

How common lung disease COPD is among adults in Taif, Saudi Arabia

This study looks at how many adults in one city already have COPD, a long-term lung disease. It also looks at what might be linked to it, like smoking and exposure to dust or fumes.

Original title: COPD Prevalence and Risk Factors Among Saudi Adults Over 18 in Taif

Opening soon · ClinicalTrials.gov · Oct 203Calorie restriction and fasting

A fasting-style diet app tested during breast cancer treatment to ease tiredness

This study is planned but has not started enrolling people yet. It will compare tiredness in people who add the program to standard treatment with those who do not.

Original title: Fasten Onco Digital Therapy During Neoadjuvant Treatment for Triple-Negative Breast Cancer

Opening soon · ClinicalTrials.gov · Oct 194Hyaluronic acid fillers

A skin device for facial wrinkles is being tested in 43 adults

This study plans to test a skin device on people with facial wrinkles. It has not started enrolling, and no results have been posted yet, so it cannot show whether the device works.

Tested in 43 adults with facial wrinkles

Original title: Evaluation of MD60002 Device for Facial Skin Aging

Opening soon · ClinicalTrials.gov · Oct 194Strength training

Ketone supplement with protein after weight training in older men: a planned trial

This trial plans to test whether a ketone drink with protein after resistance exercise changes how the body breaks down and uses protein. It has not started, so no results exist yet.

Original title: Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males

Now recruiting · ClinicalTrials.gov · Oct 184Drinking less alcohol

Study of weight and gum disease in Thai adults under 60

This is a plan to study how common high body weight and gum disease are in Thai adults aged 18 to 59. It has not started reporting results, so it cannot tell us anything yet.

Original title: Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years

Opening soon · ClinicalTrials.gov · Oct 194Vaccines for adults

New vaccine study planned for adults aged 65 and older

This trial plans to check whether a new shot is safe and triggers an immune response similar to a current shot. No results have been posted yet, so we do not know how it turned out.

Original title: Phase 2/3 Clinical Trial to Evaluate the Immunogenicity and Safety of GC3114B in Adults Aged 65 Years or Older

Opening soon · ClinicalTrials.gov · Oct 194Vaccines for adults

Comparing a high-dose and standard flu shot in older adults in Singapore

This trial plans to test whether a high-dose flu shot gives stronger antibody levels than a standard shot. It has not started recruiting, so it does not yet show whether either shot works better.

Original title: Immunogenicity of Standard-Dose Versus High-Dose Influenza Vaccines in Older Adults in Singapore

New trial · ClinicalTrials.gov · Oct 18

Sleep and frailty in people living with HIV

This registered study plans to compare sleep, physical frailty, and mouth function in people with HIV and people using PrEP. It has no results yet, so it cannot show how sleep and frailty are linked.

Original title: Sleep Quality and Frailty Among People Living With HIV

Now recruiting · ClinicalTrials.gov · Oct 182Laser resurfacing (CO2 and fractional lasers)

Does sleep apnea surgery affect swallowing and mouth strength over time

Researchers will compare people who have sleep apnea surgery with people who do not, checking swallowing and mouth function. This is a trial that has not reported results yet, so it cannot yet show what the effects are.

Original title: Effects of Surgery on Oral Frailty and Dysphagia in Patients With Obstructive Sleep Apnea

Older →