What this means
This registered study plans to compare sleep, physical frailty, and mouth function in people with HIV and people using PrEP. It has no results yet, so it cannot show how sleep and frailty are linked.
Plain-English summary written by an AI model from the registry listing.
- Status
- Completed
- Who can join
- Ages 20 and over
- Where
- 1 site
The science
- Registered title
- Sleep Quality and Frailty Among People Living With HIV
- Trial ID
- NCT07880054 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- HIV Infections, Frailty, Sleep Quality, Oral Frailty
- What is tested
- No intervention (observational assessments)
- Sponsor
- National Sun Yat-sen University
- Ages
- 20 Years to no maximum
- Dates
- First posted Oct 19, 2026 · updated Oct 19, 2026
Registry summary
With effective antiretroviral therapy (ART), people living with HIV (PLWH) are living longer and are increasingly experiencing aging-related conditions such as frailty and sleep problems. However, most frailty research has focused on the general older population, and little is known about how sleep relates to physical and oral frailty in PLWH.
This case-control study compares sleep disturbance, physical frailty, and oral hypofunction between adults living with HIV receiving ART and sex-matched HIV-negative pre-exposure prophylaxis (PrEP) users recruited from an infectious disease outpatient clinic at a medical center in southern Taiwan. The study also examines whether sleep disturbance (insomnia severity and daytime sleepiness) is associated with physical frailty and oral hypofunction, whether physical frailty represents an indirect pathway between sleep disturbance and oral hypofunction, and the roles of ART and serum Galectin-3 levels in predicting frailty among PLWH.
Sites (1)
- National Cheng Kung University Hospital, Tainan, Taiwan