What this means
This is a planned study that has not started recruiting people yet. It will test whether creatine plus walking football helps muscle and metabolism in older adults.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 50 and over
- Where
- Not listed
The science
- Registered title
- Creatine and Muscle Health in Madrid's Walking Footballers.
- Trial ID
- NCT07891936 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Muscle Adaptation, Body Composition, Physical Activity in Adults
- What is tested
- Monohydrate Creatine supplementation during Walking Football training
- Sponsor
- Universidad Europea de Madrid
- Ages
- 50 Years to no maximum
- Dates
- First posted Oct 23, 2026 · updated Oct 23, 2026
Registry summary
Healthy aging requires effective, accessible, and sustainable interventions capable of preserving functional capacity and preventing age-related decline. In this context, walking football has emerged as a safe, inclusive physical exercise modality with high adherence among older adults, demonstrating benefits for muscle health, metabolic profile, and psychosocial well-being. On the other hand, creatine monohydrate supplementation is backed by robust scientific evidence as a strategy to enhance exercise adaptations, promote muscle mass maintenance, and improve factors related to metabolic syndrome.
The objective of this project is to evaluate the effects of creatine supplementation combined with regular walking football practice on muscle quality and metabolic profile in older adults, as well as to explore the underlying biological mechanisms using a cell culture-based experimental model. The ultimate goal is to determine the potential of this intervention to promote healthy longevity through functional, muscular, and metabolic indicators associated with healthspan.
Specifically, the study will analyze the intervention's effects on body composition, physical fitness, and metabolic syndrome markers; evaluate its impact on psychosocial well-being, quality of life, and cognitive function; and investigate the molecular mechanisms related to muscle health, protection against oxidative stress, and the modulation of senescence using an ex vivo/in vitro model.
The project will be carried out in two complementary phases. First, a longitudinal experimental study will be conducted in older adults participating in walking football programs and supplemented with creatine. Subsequently, skeletal muscle cultures will be exposed to conditioned sera obtained before and after the intervention to investigate its biological effects.
This approach will integrate the evaluation of clinical efficacy with the study of the underlying mechanisms, generating applicable knowledge for designing personalized, sustainable, and cost-effective strategies to prevent sarcopenia and metabolic syndrome.