What people try
4Drinking less alcoholStage 4 · Widely recommended · FreeDrinking less alcohol means cutting back on how much you drink, which is better for health than drinking more.Main risk: Taking aspirin and drinking raises the risk of stomach or intestinal bleeding.4Knowing and controlling your blood pressureStage 4 · Widely recommended · Checks at doctors' offices and pharmacies; treatment by prescriptionHigh blood pressure, also called hypertension, is a key risk factor for heart disease and stroke, and it can be measured and managed.Main risk: Uncontrolled high blood pressure is a risk factor for heart attack, stroke, and congestive heart failure.4Too much sittingStage 4 · Widely recommended · FreeToo much sitting means long periods of low-energy time spent sitting, reclining or lying while awake.Main risk: Adults who sit a lot are linked to higher rates of death from any cause, heart disease and cancer.4Healthy eating patterns (Mediterranean, DASH, whole foods)Stage 4 · Widely recommended · Free; a change in eatingThe Mediterranean diet is a plant-focused eating plan based on the traditional foods and cooking methods of the Mediterranean region.Main risk: It says people may have lower iron levels.4Home blood pressure monitorsStage 4 · Widely recommended · Over the counter at pharmacies and onlineHome blood pressure monitoring means people measure their own blood pressure outside a clinic, using a home device.Main risk: Home monitors might not always be correct, and they do not replace medical visits.4GLP-1 drugsStage 4 · Widely recommended · PrescriptionGLP-1 drugs are a class of medicines used to treat type 2 diabetes by lowering blood sugar, and some are used for weight loss in people with obesity.Main risk: The semaglutide page warns that it may raise the risk of thyroid tumors, including a type of thyroid cancer.4MetforminStage 4 · Widely recommended · Prescription, approved for diabetesMetformin belongs to a class of drugs called biguanides.Main risk: Metformin may rarely cause a serious, life-threatening condition called lactic acidosis.4ExerciseStage 4 · Widely recommended · Free, for almost everyoneExercise is anything that gets your body moving.Main risk: Using weight machines improperly can cause back injury.4Ultra-processed foodStage 4 · Widely recommended · Free; a change in eatingUltra-processed foods are tasty, convenient foods that often contain little to no whole foods and use ingredients not found in home kitchens.Main risk: Eating a lot of these foods has been linked to a higher risk of heart disease and other serious health problems.3Calorie restriction and fastingStage 3 · Large studies in people · Free; a change in eatingCalorie restriction means eating fewer calories than usual without missing key nutrients, while fasting diets limit when or how much a person eats.Main risk: The NIA says too many ketones in the blood (chemicals made from burning fat) can have harmful health effects.3BerberineStage 3 · Large studies in people · Over-the-counter supplementBerberine is a substance found in several plants, such as goldenseal, barberry, and Oregon grape.Main risk: Berberine has been linked to a harmful buildup of bilirubin in infants, which can cause brain damage.3Omega-3 fatty acidsStage 3 · Large studies in people · Food, supplements and a prescription formMost research has focused on two omega-3s called EPA and DHA.Main risk: The pages say side effects are usually mild, such as unpleasant taste, bad breath, heartburn, nausea, and diarrhea.3Testosterone therapyStage 3 · Large studies in people · PrescriptionTestosterone therapy uses man-made testosterone to treat low testosterone, and it can be given as a pill, gel, patch, injection, or implant.Main risk: The page lists several risks of this therapy, including infertility, an enlarged prostate, blood clots, and worsening heart disease.3Protein supplementsStage 3 · Large studies in people · Over-the-counter supplementProtein is one of the more common ingredients in supplements sold to improve exercise and athletic performance.Main risk: The page says high protein intakes seem quite safe, but more than the recommended amounts gives no benefit.2Continuous glucose monitorsStage 2 · Small studies in people · Some over the counter; others by prescriptionA continuous glucose monitor is a device that measures blood sugar every few minutes using a sensor placed under the skin.Main risk: Continuous glucose monitors are described as sometimes still needing a regular meter to confirm results and set up the device.2Vitamin B12Stage 2 · Small studies in people · Over-the-counter supplement; injections by prescriptionVitamin B12 is a nutrient that helps keep blood and nerve cells healthy and helps make DNA.Main risk: The pages stress that vitamin B12 is generally considered safe, even at high doses, because the body does not store excess amounts.2RapamycinStage 2 · Small studies in people · Prescription, used off-label for agingRapamycin, also called sirolimus, is a prescription drug that suppresses the immune system and is used to prevent kidney transplant rejection.Main risk: The pages stress that it can make it harder to fight infections and raise the risk of serious infection.2ResveratrolStage 2 · Small studies in people · Over-the-counter supplementResveratrol is a chemical found in grapes, red wine, peanuts, pistachios, blueberries, and cranberries.Main risk: High doses can cause stomach and bowel side effects such as diarrhea.2QuercetinStage 2 · Small studies in people · Over-the-counter supplementQuercetin is a plant compound, called a bioflavonoid, that gives many plants their bright colors.Main risk: In a one-week trial in people with COPD, quercetin caused no severe side effects linked to the study drug, based on blood tests.2MagnesiumStage 2 · Small studies in people · Over-the-counter supplementMagnesium is a mineral the body needs, found in foods, supplements, and some medicines such as antacids and laxatives.Main risk: High doses from supplements or medicines often cause diarrhea, which can come with nausea and belly cramping.2NAD+ boostersStage 2 · Small studies in people · Over-the-counter supplementsNAD+ boosters are supplements, such as NAD+ precursors like nicotinamide riboside and NMN, meant to raise levels of NAD+, a molecule in cells that declines with age.Main risk: A review of studies found all studies reported some side effects, most often muscle pain, nervous disorders, fatigue, sleep disturbance, and headaches.2NMN (nicotinamide mononucleotide)Stage 2 · Small studies in people · Over-the-counter supplementA molecule the body uses to make NAD+, which cells need to turn food into energy.Main risk: A review of studies found that oral NMN and NR (a related compound) were generally well tolerated over weeks to months in people.2Fiber supplementsStage 2 · Small studies in people · Over-the-counter supplementPsyllium is a bulk-forming fiber laxative used to treat constipation.Main risk: Psyllium powder accidentally breathed in while mixing a dose can cause allergic reactions.2Alpha-ketoglutarate (Ca-AKG)Stage 2 · Small studies in people · Over-the-counter supplementA molecule the body makes while turning food into energy. Supplements usually use a calcium form, Ca-AKG.2CreatineStage 2 · Small studies in people · Over-the-counter supplementCreatine is a compound stored in your muscles that supplies them with energy.Main risk: Creatine can cause weight gain because it tends to make the body hold water, but it is otherwise considered safe for healthy adults.2FisetinStage 2 · Small studies in people · Over-the-counter supplementFisetin is one of three flavonols that a review looked at for prostate and bladder cancer.Main risk: The review of injury studies reported no significant side effects from fisetin.2NR (nicotinamide riboside)Stage 2 · Small studies in people · Over-the-counter supplementNR (nicotinamide riboside) is a compound that can raise levels of NAD+, a molecule in the body that declines with age.Main risk: A review of studies found oral NR was generally well tolerated over weeks to months.2Hyperbaric oxygen therapyStage 2 · Small studies in people · Hospitals and private clinicsHyperbaric oxygen therapy gives you pure oxygen in an enclosed space with higher than normal air pressure.Main risk: You might feel pressure in your ears, and they may pop afterward.2NAD+ IV and injectionsStage 2 · Small studies in people · Clinics and IV wellness centersNAD+ given by drip into a vein or by injection, instead of as a pill.2GlyNAC (glycine and NAC)Stage 2 · Small studies in people · Over-the-counter supplementsNAC is used as a drug for acetaminophen overdose and to help break up mucus.Main risk: The pages list stomach upset, diarrhea, nausea, vomiting and similar problems as the common side effects of NAC.2TesamorelinStage 2 · Small studies in people · Prescription, approved only for belly fat in HIVA lab-made version of GHRH, the brain hormone that tells the body to release growth hormone.2SermorelinStage 2 · Small studies in people · Prescription, made by compounding pharmaciesA lab-made copy of the first 29 building blocks of GHRH, the brain hormone that tells the body to release growth hormone.1MOTS-cStage 1 · Tested in animals only · Not approved; marketed onlineA small peptide made from instructions in the DNA of mitochondria, studied for how the body uses sugar and fat.1HumaninStage 1 · Tested in animals only · Not approved; studied in labsA small peptide made from instructions in the DNA of mitochondria, studied in cells and animals for protecting the brain with age.
Products
Sorted by the best research stage of each product's ingredients, then by price. The stage describes research on the ingredient, not proof that the product works.
Supplements
Multivitamin for Men GummiesVitamin D, Vitamin B123 Ingredient research: large studies in people$9.79Vitamin B12 500 mcg TabletsVitamin B12, Calcium3 Ingredient research: large studies in people$10.69Pure Krill Oil Omega-3 - 500 mg, 60 softgelsOmega-3 fatty acids3 Ingredient research: large studies in people$18.74Berberine SupplementBerberine3 Ingredient research: large studies in people$19.95Ultimate Omega 3 One DailyOmega-3 fatty acids3 Ingredient research: large studies in people$22.97Berberine Pro - 600 mg, 60 capsulesBerberine3 Ingredient research: large studies in people$29.95Berberine 1000, 1000 mg, 60 tabletsBerberine3 Ingredient research: large studies in people$29.99Basic Nutrients 2/Day - NSF Certified for SportVitamin B12, Vitamin D3 Ingredient research: large studies in people$40Whey Protein Isolate - Flavor SeriesProtein supplements3 Ingredient research: large studies in people$42.99Berberine - 30 ServingsBerberine3 Ingredient research: large studies in people$44Super EPA - NSF Certified for SportOmega-3 fatty acids3 Ingredient research: large studies in people$45BerberineBerberine3 Ingredient research: large studies in people$49.95Omega-3 with CoQ10CoQ10 (coenzyme Q10), Omega-3 fatty acids3 Ingredient research: large studies in people$55Extra Strength Omega-3 Fish Oil - 120 softgelsOmega-3 fatty acids3 Ingredient research: large studies in people$59.95Grass-Fed Whey Protein IsolateProtein supplements3 Ingredient research: large studies in people$64.99Whey Protein Isolate - VanillaProtein supplements3 Ingredient research: large studies in people$65Gold Standard 100% Isolate Whey Protein powderProtein supplements3 Ingredient research: large studies in people$103.49Vitamin B12 Time Release 1000 mcg TabletsVitamin B122 Ingredient research: small studies in people$11.29Vitamin Code Raw B-12Vitamin B122 Ingredient research: small studies in people$13.29Vitamin B12 Extra Strength GummiesVitamin B122 Ingredient research: small studies in people$13.99Vitamin B12 3000 mcg Fast Dissolve TabletsVitamin B122 Ingredient research: small studies in people$14.29Essentials NMN 300 - Nexergy™ NMN - 300 mg, 30 capsulesNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$14.96Micronised Creatine PowderCreatine2 Ingredient research: small studies in people$14.99Creatine [+]Creatine2 Ingredient research: small studies in people$16.99Vitamin B12 1000 mcg SoftgelsVitamin B122 Ingredient research: small studies in people$17.29Nicotinamide Riboside + Pterostilbene - 30 capsulesNR (nicotinamide riboside), Pterostilbene2 Ingredient research: small studies in people$17.97Psyllium Husk SupplementFiber supplements2 Ingredient research: small studies in people$19.95Pure Glycine - 1000 mg, 120 capsulesGlyNAC (glycine and NAC)2 Ingredient research: small studies in people$19.95Micronized Creatine PowderCreatine2 Ingredient research: small studies in people$20.49High Absorption Magnesium Glycinate Capsules 200 mgMagnesium2 Ingredient research: small studies in people$21.99Vitamin B12 Maximum Strength 5000 mcg SoftgelsVitamin B122 Ingredient research: small studies in people$21.99Pure N-Acetyl Cysteine - 600 mg, 120 capsulesGlyNAC (glycine and NAC)2 Ingredient research: small studies in people$22.95Psyllium Husk Caps 500 mg Veg CapsulesFiber supplements2 Ingredient research: small studies in people$23.09Doctor's Best High Absorption Magnesium, 100 mg, 240 TabletsMagnesium2 Ingredient research: small studies in people$23.99Essentials NMN 500 - Nexergy™ NMN - 500 mg, 30 capsulesNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$24.95Nicotinamide Riboside Pro 300 + 100 mg TMG - 30 capsulesNR (nicotinamide riboside)2 Ingredient research: small studies in people$24.95Calcium AKG Longevity Powder - 100 gramsAlpha-ketoglutarate (Ca-AKG)2 Ingredient research: small studies in people$24.98Advanced Collagen Peptides + Creatine - UnflavoredCollagen peptides, Creatine2 Ingredient research: small studies in people$24.99Nicotinamide Riboside Pro 500 + 250 mg TMG per serving - 60 capsulesNR (nicotinamide riboside)2 Ingredient research: small studies in people$25.17Calcium AKG Longevity - 1,000 mg per serving, 60 capsulesAlpha-ketoglutarate (Ca-AKG)2 Ingredient research: small studies in people$25.25B-Complex #12Vitamin B122 Ingredient research: small studies in people$26Magnesium Glycinate - 90 ServingsMagnesium2 Ingredient research: small studies in people$26Qualia NAD+Resveratrol2 Ingredient research: small studies in people$29GlycineGlyNAC (glycine and NAC)2 Ingredient research: small studies in people$31Trans-Resveratrol Plus - 1000 mg per serving, 60 capsulesResveratrol2 Ingredient research: small studies in people$31.08NOVOS Boost - NMN Supplement to Boost NAD+ LevelsNAD+ boosters2 Ingredient research: small studies in people$32.08Pure Quercetin - 500 mg, 90 capsulesQuercetin2 Ingredient research: small studies in people$33.57Vitamin B12 - 90 ServingsVitamin B122 Ingredient research: small studies in people$34Pure Quercetin SupplementQuercetin2 Ingredient research: small studies in people$35Senolytic ComplexSenolytics, Quercetin, Fisetin2 Ingredient research: small studies in people$35NMNR™ Pro Synergy - 90 capsulesNMN (nicotinamide mononucleotide), NR (nicotinamide riboside)2 Ingredient research: small studies in people$35.95Creatine - Travel PacksCreatine2 Ingredient research: small studies in people$36Fisetin Pro Longevity Plus - 60 capsulesFisetin2 Ingredient research: small studies in people$37Glycine + NAC PackGlyNAC (glycine and NAC)2 Ingredient research: small studies in people$38.95Fiber+ Vitamins C, D & B12 Sparkling Fiber PowderFiber supplements2 Ingredient research: small studies in people$39.39Qualia SenolyticFisetin2 Ingredient research: small studies in people$39.50Essentials NMN 1000 - Nexergy™ NMN - 1000 mg per serving, 60 capsulesNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$39.95Tru Niagen® ImmuneNR (nicotinamide riboside)2 Ingredient research: small studies in people$41ResveratrolResveratrol2 Ingredient research: small studies in people$41.95Creatine - 90 ServingsCreatine2 Ingredient research: small studies in people$42.99Creatine - 90 ServingsCreatine2 Ingredient research: small studies in people$44NAD+ Cell Regenerator™ and Resveratrol Elite™NR (nicotinamide riboside), Resveratrol2 Ingredient research: small studies in people$45Quercetin PhytosomeQuercetin2 Ingredient research: small studies in people$46QuercetinQuercetin2 Ingredient research: small studies in people$47.95CaAKGAlpha-ketoglutarate (Ca-AKG)2 Ingredient research: small studies in people$48.95Tru Niagen® 300mgNR (nicotinamide riboside)2 Ingredient research: small studies in people$49Tru Niagen® BeautyNR (nicotinamide riboside), Astaxanthin2 Ingredient research: small studies in people$49Longevity Creatine Pure Powder - 450 gramsCreatine2 Ingredient research: small studies in people$49.95Nicotinamide Riboside Pro Complete - 500 mg NR Hydrogen Malate + 500 mg Trans-Resveratrol + 100 mg TMG per serving, 60 capsulesNR (nicotinamide riboside), Resveratrol2 Ingredient research: small studies in people$49.95Brain FactorsNAD+ boosters2 Ingredient research: small studies in people$51Pure Resveratrol SupplementResveratrol2 Ingredient research: small studies in people$54NMN PowderNAD+ boosters2 Ingredient research: small studies in people$54.95NMN Pure PowderNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$54.95NMNs Fast Dissolve TabsNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$54.95Liposomal NMN Pro Complete™ - Lipo Uthever® NMN, Trans-Resveratrol, TMG, 90 capsulesNMN (nicotinamide mononucleotide), Resveratrol2 Ingredient research: small studies in people$55.95Pure Fisetin - 250 mg, 60 capsulesFisetin2 Ingredient research: small studies in people$55.95Tru Niagen® 300mg Stick PacksNR (nicotinamide riboside)2 Ingredient research: small studies in people$58NMN SLC Enteric Capsules 200NMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$58.95Niagen NanoCloud™NR (nicotinamide riboside)2 Ingredient research: small studies in people$59Longevity Collagen Complete Powder - 690 gramsGlyNAC (glycine and NAC)2 Ingredient research: small studies in people$59.95Essentials NMN Powder - Nexergy™ NMN - 100 gramsNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$59.96ResveraCelResveratrol, NR (nicotinamide riboside), Quercetin2 Ingredient research: small studies in people$60NAC - N-Acetylcysteine - 180 ServingsGlyNAC (glycine and NAC)2 Ingredient research: small studies in people$63NMN Resveratrol GelNAD+ boosters, Resveratrol2 Ingredient research: small studies in people$63.95FisetinFisetin2 Ingredient research: small studies in people$64.95NMN - Comprehensive Support for Healthy NAD+ LevelsNAD+ boosters2 Ingredient research: small studies in people$64.95NMN Liposomal CapsulesNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$64.95BasisNR (nicotinamide riboside), Pterostilbene2 Ingredient research: small studies in people$65Collagen PlusNR (nicotinamide riboside), Collagen peptides2 Ingredient research: small studies in people$67NAD Triple Boost™ with NMN - 90 capsulesPterostilbene, Resveratrol2 Ingredient research: small studies in people$67.95Rapid Reset Multi-Senolytic - 30 capsulesFisetin, Resveratrol2 Ingredient research: small studies in people$69.95Benefiber Original Powder Fiber SupplementFiber supplements2 Ingredient research: small studies in people$69.99Creatine+Creatine2 Ingredient research: small studies in people$70NiaCel® 400NR (nicotinamide riboside)2 Ingredient research: small studies in people$74Pure NMN SupplementNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$80NMN Pro Complete™ - Uthever® NMN, Trans-Resveratrol, TMG - 75 gramsNMN (nicotinamide mononucleotide), Resveratrol2 Ingredient research: small studies in people$82.95Creatine - 180 ServingsCreatine2 Ingredient research: small studies in people$84Resveratrol Pure PowderResveratrol2 Ingredient research: small studies in people$84.95Tru Niagen® 150mgNR (nicotinamide riboside)2 Ingredient research: small studies in people$94Pure Fisetin SupplementFisetin2 Ingredient research: small studies in people$95Rejuvant® LifeAKG for MenAlpha-ketoglutarate (Ca-AKG)2 Ingredient research: small studies in people$99.95Rejuvant® LifeAKG for WomenAlpha-ketoglutarate (Ca-AKG)2 Ingredient research: small studies in people$99.95Tru Niagen® Pro 1,000mgNR (nicotinamide riboside)2 Ingredient research: small studies in people$116NAD+ Powder Supplement With NMNNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$118Sublingual NMN Lozenge: Chewable NAD+ BoosterNMN (nicotinamide mononucleotide)2 Ingredient research: small studies in people$118
Devices
iHealth Track Blood Pressure MonitorHome blood pressure monitors4 This type: widely recommended$59.99iHealth Neo Wireless Blood Pressure MonitorHome blood pressure monitors4 This type: widely recommended$79.99Pro-Series Bluetooth Blood Pressure MonitorHome blood pressure monitors4 This type: widely recommended$79.995 Series® Upper Arm Blood Pressure MonitorHome blood pressure monitors4 This type: widely recommended$83.99Ultraconnect WirelessHome blood pressure monitors4 This type: widely recommended$94.6410 Series® Upper Arm Blood Pressure MonitorHome blood pressure monitors4 This type: widely recommended$118.99BPM ConnectHome blood pressure monitors4 This type: widely recommended$129.95BPM VisionHome blood pressure monitors4 This type: widely recommended$179.95Stelo Wearable Glucose BiosensorContinuous glucose monitors2 This type: small studies in people$37.99Dexcom G7 15 DayContinuous glucose monitors2 This type: small studies in people$192.52
Recent research
A proposed plan to tailor oxygen chamber treatment using biomarkers
The authors describe a framework for adjusting hyperbaric oxygen dosing based on body markers.
Short daily fasting extended lifespan in tiny worms
Worms fasted for part of each day lived longer than worms that did not fast.
Ginseng compound Rb1 eased signs of aging in the uterus in lab tests
Researchers found that Rb1 reduced aging signs in uterus lining cells and mouse uteruses.
Study plan tests a drug plus exercise for physical strength in older adults with HIV
This paper describes the plan for a trial, not its results.
Eye supplements that target aging pathways: a review of current evidence
This review looked at vitamins and similar products for eye diseases tied to aging.
What others are writing
Recent articles from health journalists, hospitals and universities. We link to them; we don't write or endorse them.
Magnesium for Sleep: Does It Really Work? ↗
Magnesium: The article says evidence that magnesium aids sleep is thin and more research is needed before routine recommendation.
Testosterone therapy without evidence of deficiency may boost heart risk ↗
Testosterone therapy: A study found men using testosterone without low-testosterone diagnosis had higher heart problem and death risk than those treated for hypogonadism.
A clearer picture of drinking and disease ↗
Drinking less alcohol: A new review finds some alcohol-related damage can be slowed or reversed by cutting down or quitting drinking.
Alcohol is the root of 62 diseases and a partial cause of dozens more ↗
Drinking less alcohol: The review finds alcohol causes dozens of diseases, and cutting down or quitting can slow or reverse many of them.
This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.