How people get it: By prescription, from compounding pharmacies. The FDA approved it as Geref in the 1990s; its maker later stopped selling it.
FDA status, evidence and safety
Compounded prescriptionPrescription; compounded by pharmacies
- FDA status
- FDA-approved as Geref (1990 and 1997), then discontinued by its maker. FDA recorded that it was not withdrawn for reasons of safety or effectiveness. Drugs@FDA ↗Drugs@FDA ↗
- Its research stage
- Stage 2 although it was once FDA-approved: that approval wasn't for aging, and its maker stopped selling it. Studies in older adults were small and short. The counts behind it
- In people so far
- 10 healthy men aged about 68 took it twice a day for 14 days: growth hormone and IGF-1 levels rose toward those of young men. PubMed ↗
- 11 healthy men aged 64 to 76 injected it nightly for 6 weeks: nighttime growth hormone rose and 2 of 6 strength tests improved, with no change in muscle or fat. PubMed ↗
- Safety
- In sport
- Banned in sport at all times: WADA names sermorelin among growth-hormone-releasing factors (class S2). WADA ↗
One of the peptides we follow. We don't give doses or say where to buy. Talk to your doctor before trying any of them.
The basics
We're still gathering this from reference sources like the NIH and MedlinePlus. Sections appear here once every sentence is checked against its source.
What it is
Not enough reliable information yet.
How it's thought to work
Not enough reliable information yet.
What people use it for
Not enough reliable information yet.
What the research has found so far
On Sermorelin and aging, PubMed lists 12 trials in people, 0 studies that watched people over time, 3 animal and lab studies. See the counts and searches
Stage 2 because 12 published trials and 34 registered trials in people have been found, but no large ones yet.
A stage shows how far research has got, not whether it will work for you. How stages work
Side effects and risks
Not enough reliable information yet.
Who should be careful, and drug interactions
Not enough reliable information yet.
What to expect
Not enough reliable information yet.
Amounts used in studies
What studies or labels describe, not a recommendation.
Not enough reliable information yet.
Roughly what it costs
We don't have prices for this yet.
Questions to ask your doctor
- Is Sermorelin a sensible option for me, given my health and the medicines I take?
- Could Sermorelin interact with any medicine or supplement I already take?
- What side effects should I watch for, and when should I stop or call you?
- Would Sermorelin be used for its approved purpose, or off-label for aging?
- How would we tell whether it is helping, and when should we review it?
This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.
What experts say
No expert views collected yet. Each one we add names the person and links to where they said it.
Recent research
New studies that mention Sermorelin appear here after the morning update.
Trials
None of the registered trials of Sermorelin is one we have linked as aging-related yet.
ClinicalTrials.gov lists 34 registered trials that mention Sermorelin, for any condition (the count in The science below). Here we show the ones about aging. See them all ↗
The science
Counted from PubMed and ClinicalTrials.gov on Oct 30, 2026, using one search for Sermorelin in relation to aging. Each link opens the exact search.
- Randomized trials in people
- 9 search ↗
- Large trials (multicenter or phase 3)
- 0 search ↗
- Phase 3 trials
- 0 search ↗
- Trials in people
- 12 search ↗
- Studies that watched people over time
- 0 search ↗
- Animal and lab studies
- 3 search ↗
- Registered trials
- 34 search ↗
PubMed search used
(sermorelin[tiab] OR "GHRH(1-29)"[tiab] OR "GRF(1-29)"[tiab] OR "GHRH 1-29"[tiab] OR "GRF 1-29"[tiab]) AND (aging[tiab] OR ageing[tiab] OR longevity[tiab] OR healthspan[tiab] OR "older adults"[tiab] OR "older people"[tiab] OR elderly[tiab] OR "Aged"[mh])
Counts are search results, so they include some records that only mention Sermorelin. How we count
Cite or share this page
Longevity Progress. (n.d.). Sermorelin: Research stage and evidence. Retrieved October 30, 2026, from https://longevityprogress.com/treatments/sermorelin
<iframe src="https://longevityprogress.com/embed/stage/sermorelin" title="Sermorelin: research stage on Longevity Progress" width="340" height="72" style="border:0" loading="lazy"></iframe>
The badge shows this treatment's current research stage and links back here. It updates by itself when the stage changes.