How people get it: Not approved for use in people. Studied in labs and animals.
FDA status, evidence and safety
Not FDA-approvedNot approved; studied in labs
- FDA status
- Not FDA-approved, and not on the FDA's lists of substances nominated for pharmacy compounding. FDA compounding list ↗FDA safety-risk list ↗
- Its research stage
- Stage 1: the trials that mention humanin measured the body's own humanin, for example after exercise; none gave it to people. The counts behind it
- In people so far
- Humanin improved thinking in old mice; in a large group of older adults, a gene variant linked to lower humanin levels went with faster cognitive aging. PubMed ↗
- Safety
- No trial that gives humanin to people is listed on ClinicalTrials.gov. ClinicalTrials.gov ↗
- In sport
- Not named on the World Anti-Doping Agency's 2026 Prohibited List. WADA ↗
One of the peptides we follow. We don't give doses or say where to buy. Talk to your doctor before trying any of them.
The basics
We're still gathering this from reference sources like the NIH and MedlinePlus. Sections appear here once every sentence is checked against its source.
What it is
Not enough reliable information yet.
How it's thought to work
Not enough reliable information yet.
What people use it for
Not enough reliable information yet.
What the research has found so far
On Humanin and aging, PubMed lists 4 trials in people, 9 studies that watched people over time, 6 animal and lab studies. See the counts and searches
Capped at stage 1: the trials this search finds measured the body's own humanin, in studies of exercise and hyperbaric oxygen (PubMed 41975304, 31134827) and trials of exercise and anesthesia (ClinicalTrials.gov NCT07438002, NCT07678073); none gave humanin to people.
A stage shows how far research has got, not whether it will work for you. How stages work
Side effects and risks
Not enough reliable information yet.
Who should be careful, and drug interactions
Not enough reliable information yet.
What to expect
Not enough reliable information yet.
Amounts used in studies
What studies or labels describe, not a recommendation.
Not enough reliable information yet.
Roughly what it costs
We don't have prices for this yet.
Questions to ask your doctor
- Is Humanin a sensible option for me, given my health and the medicines I take?
- Could Humanin interact with any medicine or supplement I already take?
- What side effects should I watch for, and when should I stop or call you?
- How would we tell whether it is helping, and when should we review it?
This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.
What experts say
No expert views collected yet. Each one we add names the person and links to where they said it.
Recent research
Rehab helped heart failure patients walk farther after a hospital stay
A hospital rehab program was linked to better walking and fitness scores at discharge.
How low-dose ketamine may affect brain support cells for mood
This paper proposes that ketamine may work mainly through astrocyte mitochondria, the energy parts of brain support cells.
Humanin protein family may help steer cell stress responses
Researchers mapped how Humanin-related proteins connect to other proteins in a computer network.
Placenta gene activity is lower in pregnancies with gestational diabetes
Researchers compared placentas from women with gestational diabetes to placentas from women with normal blood sugar.
Mediterranean diet linked to two mitochondrial proteins in older heart patients
People who followed the Mediterranean diet more closely had higher blood levels of two small proteins.
How humanin variants interact with BID and BAX proteins linked to cell death
Researchers studied how small changes to the humanin peptide affect its clumping with BID and BAX proteins.
Trials
None of the registered trials of Humanin is one we have linked as aging-related yet.
ClinicalTrials.gov lists 2 registered trials that mention Humanin, for any condition (the count in The science below). Here we show the ones about aging. See them all ↗
The science
Counted from PubMed and ClinicalTrials.gov on Oct 30, 2026, using one search for Humanin in relation to aging. Each link opens the exact search.
- Randomized trials in people
- 1 search ↗
- Large trials (multicenter or phase 3)
- 0 search ↗
- Phase 3 trials
- 0 search ↗
- Trials in people
- 4 search ↗
- Studies that watched people over time
- 9 search ↗
- Animal and lab studies
- 6 search ↗
- Registered trials
- 2 search ↗
PubMed search used
humanin[tiab] AND (aging[tiab] OR ageing[tiab] OR longevity[tiab] OR healthspan[tiab] OR "older adults"[tiab] OR "older people"[tiab] OR elderly[tiab] OR "Aged"[mh])
Counts are search results, so they include some records that only mention Humanin. How we count
Cite or share this page
Longevity Progress. (n.d.). Humanin: Research stage and evidence. Retrieved October 30, 2026, from https://longevityprogress.com/treatments/humanin
<iframe src="https://longevityprogress.com/embed/stage/humanin" title="Humanin: research stage on Longevity Progress" width="340" height="72" style="border:0" loading="lazy"></iframe>
The badge shows this treatment's current research stage and links back here. It updates by itself when the stage changes.