How humanin variants interact with BID and BAX proteins linked to cell death
Researchers studied how small changes to the humanin peptide affect its clumping with BID and BAX proteins. The work helps explain how humanin may influence cell death, but it does not show this happens in people.
Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility.
Female infertility affects approximately 17.5% of adults worldwide. Mitochondria are central to oocyte developmental competence, and a novel class of mitochondrial genome-encoded peptides, mitochondrial-derived…
Humanin peptide may slow aging changes in brain-like cells grown in a dish
Researchers gave a peptide called humanin to nerve cells in a lab dish. It reduced signs of cell aging and helped cells keep releasing brain chemicals. This is a lab study, so it does not show the same effect in people.
Humanin may ease liver damage in mice with a serious Klebsiella infection
Mice given Humanin before infection had less liver damage and less inflammation than untreated mice. This was tested in mice and cells, so it does not show the same effect in people.
Mitochondrial Peptide SHLP2 Limits Poly(I: C)-Induced Alveolar Epithelial Injury by Modulating Redox, Apoptotic, Inflammatory, and Inflammasome Responses.
Type II alveolar epithelial (ATII) cells play a central role in pulmonary homeostasis, epithelial repair, and innate antiviral defense.
The MTRNR2L gene family and age-related macular degeneration.
Age-related macular degeneration (AMD) is the leading cause of blindness in aging adults, yet no FDA-approved therapies exist for early and intermediate disease.
Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.
Cardiovascular disease is strongly influenced by mitochondrial dysfunction, yet how mitochondrial stress is communicated beyond the affected cell to coordinate systemic responses remains incompletely understood.
Rehab helped heart failure patients walk farther after a hospital stay
A hospital rehab program was linked to better walking and fitness scores at discharge. It did not clearly lower heart problems over six months, and the study was not randomized.
How low-dose ketamine may affect brain support cells for mood
This paper proposes that ketamine may work mainly through astrocyte mitochondria, the energy parts of brain support cells. It is a hypothesis-driven review, so these ideas are not yet proven.
A modified humanin peptide was tested in rats with kidney injury from blocked blood flow
Researchers gave a modified peptide to rats whose kidneys had lost and regained blood flow. The peptide helped some damage markers, but kidney urea and creatinine levels did not improve.
A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling.
α-Helical nanopores are attractive molecular sensors, yet their rational design and assembly remain challenging.
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
Background. Chronic kidney disease [CKD] is characterized by increased glycoxidative stress, inflammation, and mitochondrial dysfunction.
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review.
BACKGROUND: Type 2 diabetes mellitus and metabolic diseases are increasing worldwide and are closely linked to mitochondrial dysfunction.
Dihydroquercetin alleviates mitochondrial dysfunction and inhibits NLRP3-mediated pyroptosis in primary hepatocytes from chronic liver failure patients.
OBJECTIVE: To investigate the protective effects of dihydroquercetin (DHQ) on mitochondrial function in primary hepatocytes from patients with chronic liver failure (CLF) and discuss the underlying molecular mechanism.
Emerging regulators of human physiology and disease; sORF-encoded microproteins.
The human genome contains hundreds of thousands of short open reading frames (sORFs), yet their translational products, hereafter referred to as sORF-encoded microproteins (also historically termed micropeptides), have…
Humanin protein family may help steer cell stress responses
Researchers mapped how Humanin-related proteins connect to other proteins in a computer network. They suggest these proteins may guide stress responses, not just act alone. This is a model, so it does not show these proteins work this way in people.
A humanin analog eased kidney damage in diabetic mice and cells
Researchers found a treated protein reduced kidney damage and cell death in diabetic mice. This work was in mice and cells, so it does not show the same effect in people.
Humanin eased sexual problems caused by an antidepressant in male rats
In rats given an antidepressant, a natural peptide improved sexual behavior, sperm measures, and hormone levels. This was tested in rats, not people, so it does not show the same effect in humans.
Humanin-G shows possible vision help in rats with retinal disease
Rats given a high dose of this peptide had changes in gene activity and better vision scores in one test. The study was in rats, so it does not show whether it would help people.
Humanin treatment eased heart damage in diabetic mice
Mice with diabetes that got daily humanin for 15 days had less stress, inflammation, and cell death in the heart. This was tested in mice only, so it does not show the same would happen in people.
Placenta gene activity is lower in pregnancies with gestational diabetes
Researchers compared placentas from women with gestational diabetes to placentas from women with normal blood sugar. Lower levels of small humanin-like peptide genes showed up in the diabetes group, and were linked to higher insulin resistance and blood sugar markers.
Bioprinted bonoid-on-a-chip model for studying drug effects on human osteocyte differentiation.
Osteocytes form an extensive dendritic network within bone tissue that senses mechanical and biochemical stimuli, critical for bone homeostasis.
Humanin eased testicular damage in diabetic mice
Mice with diabetes had more oxidative stress and testicle damage. Humanin treatment improved these signs, but this study was done only in mice.
Humanin, a small mitochondrial peptide, protected ovary cells from oxidative damage in lab tests
Researchers found that humanin helped human ovary cells and rat ovary tissue survive damage from oxidative stress. This was tested in cells and tissue, not people, so it does not show effects in humans.