Peptide SS-31 eased radiation-caused aging signs in heart cells
Researchers exposed heart cells to radiation and gave some of them SS-31. SS-31 reduced several aging signs, but this was only tested in cells, not people.
Original title: Mitochondrial-targeted SS-31 peptide attenuates radiation-induced cardiomyocyte senescence.
Home exercise may change muscle in people with kidney disease
A small trial found changes in muscle blood vessels and fewer fibrosis-linked cells after 12 weeks of home exercise. Only 25 people took part, so this does not prove the exercise caused lasting muscle benefits.
Original title: Skeletal muscle adaptation to home-based exercise in chronic kidney disease.
AI scores facial aging signs and estimates how old a face looks
An AI system graded signs of aging in women's faces and guessed how old they looked. It was checked only on its own image set, not on new groups of people.
Original title: AI-Based Grading of Facial Aging Signs and Prediction of Visible Age From Standardized Facial Images: Algorithm Development and Internal Evaluation Study.
Cancer patients with symptoms may show faster epigenetic aging, a review finds
Researchers reviewed 10 studies on symptoms, stress, resilience, and aging markers in cancer patients. Most studies linked more symptoms with faster epigenetic aging, but more long-term studies are needed.
Original title: Systematic Review of the Literature on Associations Between Symptoms, Stress, Resilience, and Epigenetic Aging in Patients With Cancer.
Eye supplements that target aging pathways: a review of current evidence
This review looked at vitamins and similar products for eye diseases tied to aging. It says early signs look promising, but long-term benefit is not yet proven.
Original title: Retinal neurodegeneration as accelerated ocular aging: a review of nutritional and metabolic supplements.
A review of Ayurvedic herbs and how they may affect aging
This review looks at how several Ayurvedic herbs might work in the body to support healthy aging. It does not show that these herbs slow aging or extend life in people.
Original title: Molecular mechanisms and therapeutic potential of Rasayana in cellular protection and healthy aging.
Mouse study links astrocyte FGF13 levels to whole-body aging and inflammation
Researchers reported in Aging Cell that increasing FGF13 in astrocytes reduced aging across the bodies of mice. Knocking out FGF13 in astrocytes of aging mice worsened cognition, senescence and blood inflammatory cytokines.
Original title: An Astrocytic Factor Slows Whole-Body Aging in Mice
Stem cells and exosomes studied for organ aging in animals
This is a review of 34 animal studies on stem cells and exosomes. It suggests these treatments may help aging organs, but the review does not show they work in people.
Original title: Stem Cell and Exosome Treatment for Organ Health and Longevity.
How aging-like cell stress may affect the eye's surface
This review summarizes earlier studies on senescence, a state where cells stop dividing and release inflammatory signals. It suggests this state can help or harm the eye's surface, depending on the situation.
Original title: Cellular Senescence in Ocular Surface Diseases: Molecular Mechanisms and Therapeutic Perspectives.
A review proposes ways to measure aging and test lifestyle changes
This review suggests a plan for studying how lifestyle affects aging in people. It does not show that any lifestyle change slows aging.
Original title: Lifestyle-Associated Biomarkers of Cellular and Whole-Organism Aging: A Practical Roadmap for Human Geroscience Trials.
Gut bacteria may relate to how fast people age, early study finds
Researchers found some gut bacteria patterns linked to a measure of aging pace. This is a small early study, and the links are only ideas to test later.
Original title: Gut microbiome signatures associate with DNA methylation-based biological aging.
How aging muscle may affect the whole body
This review summarizes how muscles change with age and how they may affect other organs. It describes possible ways to help muscles, but it does not test any treatment.
Original title: Skeletal Muscle Aging Is a Significant Contributor to Systemic Aging.
How histone H1 proteins change in drug-aged breast cancer cells
Scientists found some H1 proteins rose and others fell when cancer cells were pushed into senescence. Changing one H1 protein did not fully copy the drug effect.
Original title: Dynamic Changes of Histone H1 Variants in Drug-Induced Senescence.
Three common treatments and their possible links to aging and heart health
This review summarizes earlier studies on metformin, SGLT2 inhibitors, and fasting, and suggests a plan for using them together. It notes that key trials for fasting and for metformin in people without diabetes are missing.
Original title: Metformin, SGLT2 Inhibitors, and Intermittent Fasting: Convergent Pathways to Healthspan Extension, Cardiovascular Longevity, and Cancer Prevention-A Narrative Review.
A food pattern linked to slower aging signs and fewer deaths in studies
Researchers built a diet score linked to slower epigenetic aging and lower death rates. These studies show links, not proof that the diet slows aging.
Original title: An epigenetic aging-informed dietary pattern is associated with a spectrum of aging-related health outcomes.
Exercise programs may help older adults' mood, social life and some strength tests
This review combined 25 controlled trials of physical activity in older adults. It found gains in social life, mood and some physical tests, but not in every area.
Original title: Effects of physical activity intervention on active ageing and physical function among older adults: a systematic review and meta-analysis.
Whey protein and vitamin D may lower some inflammation markers in heart rehab patients
Heart rehab patients took a whey protein and vitamin D drink for two weeks, and some inflammation markers dropped. The study was small and exploratory, so it cannot show that the supplement caused these changes.
Original title: An Exploratory Randomized Clinical Trial to Assess the Effects of Vitamin D and Leucine-Enriched Whey Protein Supplementation on Inflammaging and Gut Eubacterial Biomass in Cardiac Rehabilitation Patients.
Lung scan bone density may predict spine fractures in heavy smokers
Researchers checked bone density from lung scans against later spine fractures and deaths. Higher risk showed up for people with low bone density, but this is one older study.
Original title: Automated Opportunistic Bone Mineral Density Assessment at Low-Dose CT Lung Cancer Screening: Incident Vertebral Fractures and Mortality.
A new idea about Okinawa's diet over a lifetime and long lives
This review proposes an idea that the order of diet changes across a life may affect healthy aging. It does not prove cause, and the authors say their idea needs testing.
Original title: Lean-to-Rich Healthy Aging: A New Hypothesis on Okinawa's Postwar Nutrition Transition and Longevity Trends.
Malate may protect skin from sun damage in cells and mice
Researchers found a natural acid called malate eased sun-related aging signs in skin cells and mice. This does not show it works the same way in people, and more testing is needed.
Original title: L-Malate Protects Skin Against Ultraviolet-Induced Ferro-Aging.
A review of how resilience may help judge aging in older adults
This review looks at ideas about resilience, the body's ability to bounce back, in aging. It is a summary of existing work, not a new test, so it cannot show that resilience measures work.
Original title: [Theory of resilience in geriatric medicine.].
Computer study ranks possible drugs for kidney damage from diabetes
Researchers used open data on kidney tissue and drug patterns to rank drugs that might target aging cells. This is a computer study, so it suggests ideas but does not prove any drug works.
Original title: Senescence-Associated Transcriptome Reversal Prioritizes Repurposing Candidates for Diabetic Kidney Disease: A Computational Study.
SRSF1 gene factor rejuvenates aged mouse cells and extends mouse lifespan by 14%
Researchers identified SRSF1, an RNA-processing and splicing factor, using a transcriptomic aging model built on fibroblasts from people aged 1 to 96. Inducing SRSF1 rejuvenated human cells in vitro and, in aged mice, reduced frailty by 44%, accelerated wound closure, reduced mortality risk, and…
Original title: Rejuvenation Factor Extends Lifespan and Healthspan in Mice
Transplanted mouse ovaries take on the biological age of their recipients, study reports
Researchers led by Sharif Iqbal at Harvard Medical School transplanted ovaries between young mice and older mice and built an ovarian clock based on gene expression and DNA changes. Older ovaries became molecularly younger in young mice, and young ovaries became older in old mice.
Original title: Transplanted ovaries adjust to the recipient’s biological age
Researchers Debate Whether GLP-1 Drugs Can Extend Human Lifespan
The Scientist reports that researchers and drug developers are weighing in on whether GLP-1 drugs such as semaglutide have real potential as longevity medicines. The teaser indicates the question remains unresolved.
Original title: Can GLP-1 Drugs Extend Lifespan? The Jury Is Still Out
How a protein called SIRT2 may affect metabolism and aging
This is a review that gathers earlier studies on SIRT2, a protein that helps control how cells use energy. It does not show that SIRT2 changes how long people live.
Original title: SIRT2 in metabolism, aging, and longevity.
Sarcopenia may be better seen as a problem of the whole motor system
The authors suggest that age-related muscle loss involves nerves and brain signals, not just muscle. They argue this view could guide better testing and treatments, but this is a proposal, not a test result.
Original title: Reframing sarcopenia as a disease of the ageing motor system.
Hydroxyproline with amino acids extended worm lifespan in lab tests
Researchers gave worms hydroxyproline plus three amino acids and saw longer life and better health markers. This was tested under set lab conditions, so it does not show the same effect in people.
Original title: Hydroxyproline Enhances Branched-Chain Amino Acid Effects on Lifespan and Healthspan in Caenorhabditis elegans.
Long-lived clams show different metabolic patterns in their tissues
Researchers compared five clam species that live from about 30 to over 500 years. Long-lived clams had different levels of certain energy-related chemicals in their gills and mantle.
Original title: Metabolomic Signatures of Longevity in Bivalves Reveal Reorganization of TCA Cycle and Amino Acid Metabolism.
A drug called ruxolitinib eased eye blood vessel growth in lab and rat studies
Researchers tested ruxolitinib in aging eye cells and in rats with eye blood vessel growth. The drug reduced leakage and growth, and looked safe for one month.
Original title: The potential of ruxolitinib as a senomorphic therapy in alleviating neovascular age-related macular degeneration : Ruxolitinib inhibits CNV.