What happened
Researchers identified SRSF1, an RNA-processing and splicing factor, using a transcriptomic aging model built on fibroblasts from people aged 1 to 96. Inducing SRSF1 rejuvenated human cells in vitro and, in aged mice, reduced frailty by 44%, accelerated wound closure, reduced mortality risk, and extended median lifespan by 14%. The mouse experiment was small, with 9-10 female mice per group, and the authors say future studies are needed to explain the mechanism.
“SRSF1 was the most robust hit for transcriptomic rejuvenation (comparable to OSKM).” — The study authors
Plain-English summary written by an AI model from the Lifespan.io story; the quote is copied word for word from it.
The original
- Headline
- Rejuvenation Factor Extends Lifespan and Healthspan in Mice
- From
- Lifespan.io (news report)
- Published
- Oct 28, 2026
A recent study identified SRSF1, an RNA-processing and splicing factor, as a molecule with geroprotective potential. Inducing SRSF1 expression rejuvenated human cells in […]