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Mouse study links astrocyte FGF13 levels to whole-body aging and inflammation

News report · Lifespan.io · Oct 29, 2026

What happened

Researchers reported in Aging Cell that increasing FGF13 in astrocytes reduced aging across the bodies of mice. Knocking out FGF13 in astrocytes of aging mice worsened cognition, senescence and blood inflammatory cytokines. Raising FGF13 in older mice improved memory tests, reduced some tissue senescence and lowered inflammatory cytokines, and the authors said human testing is still needed.

“suggesting that a treatment to increase FGF13 in the astrocytes of older people may improve multiple age-related conditions”

Plain-English summary written by an AI model from the Lifespan.io story; the quote is copied word for word from it.

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The original

Headline
An Astrocytic Factor Slows Whole-Body Aging in Mice
From
Lifespan.io (news report)
Published
Oct 29, 2026

In Aging Cell, researchers have described how increasing fibroblast growth factor 13 (FGF13) in astrocytes reduces aging throughout the bodies of mice. A factor from a well-known family FGFs are signaling molecules […]

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