What this means
This review looks at ideas about resilience, the body's ability to bounce back, in aging. It is a summary of existing work, not a new test, so it cannot show that resilience measures work.
Plain-English summary written by an AI model from the abstract. The original is below.
- Who it was tested in
- A review of earlier studies, no number given
- Kind of research
- A summary of earlier studies
The science
- Original title
- [Theory of resilience in geriatric medicine.].
- Authors
- Yarotsky SY, Prashchayeu KI, Ilnitski AN et al.
- Journal
- Advances in gerontology = Uspekhi gerontologii
- Published
- Oct 27, 2026
- Study type
- Review · in humans
- PMID
- 42935332 ↗
Abstract
This review examines current perspectives on the theory of resilience as a promising concept in geriatrics and longevity medicine. Modern data on the biological mechanisms of aging, risk factors for age-associated diseases, the concept of biological age, epigenetic clocks, and proxy diseases of aging were analyzed. It has been demonstrated that chronological age does not adequately reflect individual differences in aging rates and functional status. Therefore, particular importance is attributed to integrated indicators capable of assessing adaptive reserves and the organism's resistance to age-related changes. The review discusses the potential application of epigenetic clocks as molecular biomarkers of biological aging, as well as the role of sarcopenia, frailty, cognitive impairment, and metabolic disorders as proxy diseases of aging. These conditions are shown to reflect the systemic nature of age-related changes and to be associated with decreased functional independence and increased mortality risk. Resilience is considered a comprehensive proxy clinical characteristic integrating functional, cognitive, metabolic, and psychosocial aspects of aging. The use of resilience may facilitate early risk stratification, personalization of preventive interventions, and monitoring of the effectiveness of longevity medicine programs. The concept of age-related viability represents a promising direction in modern geriatrics and requires further standardization and clinical validation.
Yarotsky SY, Prashchayeu KI, Ilnitski AN et al. [Theory of resilience in geriatric medicine.]. Advances in gerontology = Uspekhi gerontologii. 2026. doi:10.34922/AE.2026.39.4.006. PMID: 42935332. https://pubmed.ncbi.nlm.nih.gov/42935332/