Skin firmness and body changes with age: what the research says about Collagen peptides, Radiofrequency skin tightening, Microneedling

What people try

2Collagen peptidesStage 2 · Small studies in people · Over-the-counter supplementCollagen peptides, also called hydrolyzed collagen, are collagen supplements taken by mouth that have been studied for skin aging.2Radiofrequency skin tightening (e.g. Thermage)Stage 2 · Small studies in people · Dermatologists and med spasA device heats the deeper layers of the skin with radiofrequency energy to tighten it and prompt new collagen, without breaking the surface.2Microneedling (including RF microneedling)Stage 2 · Small studies in people · Dermatologists, med spas and home rollersMicroneedling is a non-surgical treatment that has become popular for facial skin aging.Main risk: A review of studies found the most common side effects were temporary redness, scaling, burning sensation and itching.2Vitamin C serumStage 2 · Small studies in people · Over the counter (serums)Vitamin C, also called ascorbic acid, is a water-soluble vitamin found in foods and sold as a supplement.Main risk: Too much vitamin C can cause upset stomach, vomiting, and loose stools.

Products

Sorted by the best research stage of each product's ingredients, then by price. The stage describes research on the ingredient, not proof that the product works.

Supplements 7

Vital ProteinsAdvanced Collagen Peptides + Creatine - UnflavoredCollagen peptides, Creatine2 Ingredient research: small studies in people$24.99 Vital ProteinsCollagen Peptides - UnflavoredCollagen peptides2 Ingredient research: small studies in people$27 ProHealth Longevity · capsulePro Collagen Activator - 120 capsulesCollagen peptides2 Ingredient research: small studies in people$28.95 Vital ProteinsCollagen Peptides Advanced - with Hyaluronic Acid & Vitamin CCollagen peptides2 Ingredient research: small studies in people$29.99 Vital ProteinsMarine Collagen - UnflavoredCollagen peptides2 Ingredient research: small studies in people$39 ProHealth LongevityPure Collagen Peptides - 20 grams per serving, 600 gramsCollagen peptides2 Ingredient research: small studies in people$39.95 ThorneCollagen PlusNR (nicotinamide riboside), Collagen peptides2 Ingredient research: small studies in people$67

Recent research

Lab study in Two types of human disc cells grown in a lab dish

Protein NEDD4 may protect disc cells from aging and cell death in a lab test

Researchers grew disc cells in a dish with an inflammation signal.

New trial

Can an AI-chosen skincare routine help aging skin in women 35 to 65?

This study will test whether a skincare plan picked by an AI tool improves fine lines, wrinkles, and skin tone.

Lab study in Roundworms (C. elegans)

Gonad collagens help worms keep eggs healthy as they age

Scientists found that certain collagens in worm reproductive tissue helped keep eggs and embryos in good shape.

See all the latest research →

What others are writing

Recent articles from health journalists, hospitals and universities. We link to them; we don't write or endorse them.

Cleveland Clinic · Beth Czerwony, RD, LD · Jun 8, 2026

Collagen Peptides: Benefits and Side Effects ↗

Collagen peptides: A Cleveland Clinic dietitian explains that collagen peptides may support skin, joints and bones, but research is mixed and results are not guaranteed.

health.harvard.edu · Toni Golen, MD · Jun 1, 2025

Do collagen supplements fulfill their promises? ↗

Collagen peptides: The article says collagen supplements may have some benefits, but research is early and large-scale studies are needed to confirm them.

This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.

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