What this video covers
A video from ARDD, posted on Oct 22, 2026. It is about drugs tested against aging and the science of aging. It names Metformin.
It comes from a research institute, foundation or scientific meeting on aging. We link to it; we don't make or endorse it. Research stages on this site come from published studies, not from videos.
Drugs tested against aging: the research →The science of aging: the research →
From the video's description
Jonathan Gootenberg, Harvard Medical School, presents at the 13th Aging Research and Drug Discovery Meeting: Proteomic Clocks for Target Nomination Key takeaways: – Proteomics offers interpretable, organ-resolved signals that correlate strongly with age and disease risk. – Clocks built on biologically defined protein subsets transfer between UK Biobank and All of Us; organ clocks best predict related outcomes (e.g., heart clock for cardiovascular mortality). – Drug effects need careful interpretation: metformin raises clock age through GDF15 induction, a marker effect. – Mendelian randomization separates drivers from markers: GDF15 is strongly linked to mortality but appears non-causal, while FES and FURIN show causal evidence. – Clocks may serve as surrogate endpoints only after rigorous validation, since they can move without outcomes changing, and vice versa. The Aging Research and …
Written by ARDD on YouTube.
