How people get it: Mostly inside clinical trials. Some, such as quercetin and fisetin, are sold as supplements.
Part of Age reversal: clearing old cells
The basics
What it is
Navitoclax is a pill-form drug that blocks Bcl-2 proteins and promotes apoptosis, which is cell death.
How it's thought to work
Senescent cells in melanoma release a mix of signals called SASP that changes how immune cells are recruited and work.
What the research has found so far
- A review of animal studies found quercetin improved cartilage scores in osteoarthritis, a joint disease linked to aging.
- The review authors said human trials are still needed to check if quercetin works for osteoarthritis.
- A review of studies said clinical use of senescence-targeting approaches in melanoma needs more study to confirm safety and benefit.
Sources: PubMed abstract: pubmed.ncbi.nlm.nih.gov ↗ · PubMed abstract: Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment. ↗
Clear results in animals. Early human trials are small.
On Senolytics and aging, PubMed lists 20 trials in people, 19 studies that watched people over time, 372 animal and lab studies. See the counts and searches
Stage 2 because 20 published trials and 41 registered trials in people have been found, but no large ones yet.
A stage shows how far research has got, not whether it will work for you. How stages work
Side effects and risks
In cancer patients, navitoclax caused a drop in platelets, which are blood cells that help clotting.
Amounts used in studies
What studies or labels describe, not a recommendation.
Studies of navitoclax in 256 cancer patients used oral doses from 10 to 475 mg. Those studies gave navitoclax on a 14 of 21 day schedule or as a continuous once daily schedule.
Roughly what it costs
The one product we list that contains Senolytics costs $35, as read from the makers' pages. See the products
Questions to ask your doctor
- Is Senolytics a sensible option for me, given my health and the medicines I take?
- Could Senolytics interact with any medicine or supplement I already take?
- What side effects should I watch for, and when should I stop or call you?
- Would Senolytics be used for its approved purpose, or off-label for aging?
- How would we tell whether it is helping, and when should we review it?
This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.
Products that contain it
Read from each maker's page. The research stage is for the ingredient, not proof that a product works.
What experts say
No expert views collected yet. Each one we add names the person and links to where they said it.
Commentary in journals
Recent research
Aging cells that support stem cells may disrupt them through chemical signals
This is a review that pulls together older and newer studies.
Mixing a senescence-clearing drug with trametinib slowed glioma regrowth in mice
Researchers found a drug combination that cleared aging-like tumour cells in mice and slowed regrowth.
New fluorescent sensor detects cells aging from cancer and lung drugs
Researchers built a glowing probe that lights up only in certain aged cells.
Review of how the FOXO4 protein may guard cells against damage and aging
This review sorted past studies on FOXO4 by how directly they tested it.
A vaccine-style treatment in mice eased diabetes signs and aged cell markers
Mice given a treatment aimed at a virus-like gene showed less weight gain and better blood sugar control.
Chinese team's senolytic nanovaccine extends median lifespan 12% in naturally aged mice
Researchers in China published in Advanced Science a three-part senolytic nanovaccine targeting dendritic cells.
Trials
ClinicalTrials.gov lists 41 registered trials that mention Senolytics, for any condition (the count in The science below). Here we show the ones about aging. See them all ↗
The science
Counted from PubMed and ClinicalTrials.gov on Oct 30, 2026, using one search for Senolytics in relation to aging. Each link opens the exact search.
- Randomized trials in people
- 11 search ↗
- Large trials (multicenter or phase 3)
- 1 search ↗
- Phase 3 trials
- 0 search ↗
- Trials in people
- 20 search ↗
- Studies that watched people over time
- 19 search ↗
- Animal and lab studies
- 372 search ↗
- Registered trials
- 41 search ↗
PubMed search used
(senolytic*[tiab] OR "dasatinib and quercetin"[tiab] OR "dasatinib plus quercetin"[tiab])
Counts are search results, so they include some records that only mention Senolytics. How we count
Cite or share this page
Longevity Progress. (n.d.). Senolytics: Research stage and evidence. Retrieved October 30, 2026, from https://longevityprogress.com/treatments/senolytics
<iframe src="https://longevityprogress.com/embed/stage/senolytics" title="Senolytics: research stage on Longevity Progress" width="340" height="72" style="border:0" loading="lazy"></iframe>
The badge shows this treatment's current research stage and links back here. It updates by itself when the stage changes.