Chinese team's senolytic nanovaccine extends median lifespan 12% in naturally aged mice

What happened

Researchers in China published in Advanced Science a three-part senolytic nanovaccine targeting dendritic cells. In mice, vaccination reduced senescence markers in fat, improved glucose tolerance and liver fat, and in naturally aged mice vaccinated at 75 weeks extended median lifespan by 12%. The authors note the lifespan experiments were small, with 10 mice per group, and the control mice were relatively short-lived.

“Mice that received the CK5 vaccine had a 12% longer median lifespan than untreated controls.” — Study authors

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