Targeting of Protein Persulfidation in Aging and Age-Related Disorders.
Aging is associated with a progressive loss of proteostasis and increased susceptibility to neurodegenerative and metabolic disorders.
Eye supplements that target aging pathways: a review of current evidence
This review looked at vitamins and similar products for eye diseases tied to aging. It says early signs look promising, but long-term benefit is not yet proven.
SIRT1-Redox Crosstalk in Aging: Adaptive Capacity and Cellular State Transitions.
Aging gradually reduces the ability of cells to maintain and restore homeostasis under metabolic and oxidative stress.
Nicotinamide Mononucleotide-Producing Probiotic Strain B12-N Attenuates Aging and Cognitive Decline in a Caenorhabditis elegans Model of Alzheimer's Disease:…
Nicotinamide mononucleotide (NMN) is an active component found in probiotics that may help alleviate Alzheimer's disease and the effects of aging.
Sirtuin-1 in Hypertension: Linking Oxidative Stress and Mitochondrial Dysfunction to Vascular Aging and Therapeutic Potential.
Hypertension is a multifactorial cardiovascular disorder characterized by oxidative stress, endothelial dysfunction, chronic inflammation, mitochondrial impairment, and accelerated vascular aging, all of which…
How a protein called SIRT2 may affect metabolism and aging
This is a review that gathers earlier studies on SIRT2, a protein that helps control how cells use energy. It does not show that SIRT2 changes how long people live.
Hydroxyproline with amino acids extended worm lifespan in lab tests
Researchers gave worms hydroxyproline plus three amino acids and saw longer life and better health markers. This was tested under set lab conditions, so it does not show the same effect in people.
Resveratroloside alleviates senescence-associated phenotypes in vitro through the coordinated regulation of mitochondrial function and chromatin structure.
Cellular senescence is characterized by coordinated disruptions in mitochondrial function and epigenetic regulation, with perturbation of the mitochondria-chromatin axis emerging as a central hallmark of this process.
The sirtuin family: from mechanisms to therapy.
Sirtuins (SIRT1-SIRT7) are evolutionarily conserved NAD+-dependent deacylases that function as metabolic sensors, coupling cellular metabolic state to epigenetic, transcriptional and post-translational regulatory…
A Cilia-Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging.
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite that regulates diverse cellular metabolic processes. Primary cilia, hair-like organelles on the cell surface, function as critical signaling hubs.
A drug that activates SIRT6 improved spinal disc health in aging mice
Researchers gave older mice a drug called MDL-800 for a long time and checked their spinal discs. The discs looked healthier, but this was done in mice, so it does not show the same effect in people.
Mitochondria-targeted drug delivery systems for aging-related diseases: Mechanisms, strategies, and advances.
Mitochondrial dysfunction, characterized by increased oxidative stress, impaired energy metabolism, disrupted mitochondrial dynamics, abnormal quality control, and activation of apoptosis, represents a critical…
Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes.
Degenerative musculoskeletal disorders, including osteoarthritis (OA), intervertebral disc degeneration (IVDD), and osteoporosis (OP), are increasingly viewed as disorders of mitochondrial quality control (MQC) rather…
How a body chemical called NAD+ may relate to Parkinson's disease
This review summarizes earlier work on NAD+, a chemical that helps cells make energy. Its levels fall with age and are lower in the brains of people with Parkinson's.
Immune cells in aging bone marrow and how they affect bone loss in mice
Researchers found a signal in bone marrow immune cells that links fat buildup to weaker bone formation. Blocking it with NMN in mice reduced bone loss, but this does not show the same happens in people.
Two drugs together eased stroke brain damage in mice
Researchers gave mice two compounds, alone and together, after a stroke-like injury to the brain. The mice given both had less brain damage and better nerve function than those given either one alone.
Trained older adults showed muscle changes that looked more like those of younger adults
Researchers studied muscle from younger and older people, some fit and some less fit, before and after one bout of exercise. Half of the age-related muscle differences were missing in trained older adults.