What this means
Nicotinamide mononucleotide (NMN) is an active component found in probiotics that may help alleviate Alzheimer's disease and the effects of aging. 25 μg of NMN per 109 CFU, as determined by LC-MS analysis of bacterial cell extracts.
A plain-English summary is on its way. Until then, this is the start of the authors' own summary.
- Who it was tested in
- Not stated
- Kind of research
- A study
The science
- Original title
- Nicotinamide Mononucleotide-Producing Probiotic Strain B12-N Attenuates Aging and Cognitive Decline in a Caenorhabditis elegans Model of Alzheimer's Disease: Efficacy and Underlying Mechanisms.
- Authors
- Wang X, Wu S, He J et al.
- Journal
- Foods (Basel, Switzerland)
- Published
- Oct 27, 2026
- Study type
- Study
- PMID
- 42940294 ↗
Abstract
Nicotinamide mononucleotide (NMN) is an active component found in probiotics that may help alleviate Alzheimer's disease and the effects of aging. The screened NMN-producing strain, Ligilactobacillus salivarius B12-N, contained 6.25 μg of NMN per 109 CFU, as determined by LC-MS analysis of bacterial cell extracts. The results indicate that B12-N showed a slightly greater numerical improvement in chemotactic behavior than purified NMN. However, no significant differences were observed between B12-N and NMN in other AD-related or aging-associated phenotypes examined. Transcriptome analysis revealed that 16 pathways were common to both the NMN group and the B12-N group. Notably, the P450 metabolism pathway, longevity regulation pathway, and autophagy pathway were significantly enriched. These findings indicate partially overlapping phenotypic and transcriptomic responses to B12-N and NMN, suggesting that NMN may contribute to some of the biological effects associated with B12-N.
Wang X, Wu S, He J et al. Nicotinamide Mononucleotide-Producing Probiotic Strain B12-N Attenuates Aging and Cognitive Decline in a Caenorhabditis elegans Model of Alzheimer's Disease: Efficacy and Underlying Mechanisms. Foods (Basel, Switzerland). 2026. doi:10.3390/foods15203657. PMID: 42940294. https://pubmed.ncbi.nlm.nih.gov/42940294/
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