Short daily fasting extended lifespan in tiny worms
Worms fasted for part of each day lived longer than worms that did not fast. This work was in worms, so it does not show the same would happen in people.
Calorie restriction uncouples mutation rate from lifespan.
In this issue of Cell, Grońska-Pęski et al. examine how calorie restriction (CR) affects DNA mutation rates.
Three common treatments and their possible links to aging and heart health
This review summarizes earlier studies on metformin, SGLT2 inhibitors, and fasting, and suggests a plan for using them together. It notes that key trials for fasting and for metformin in people without diabetes are missing.
Midlife time-restricted feeding preserves skeletal muscle insulin responsiveness and function during aging.
Primary sarcopenia, the progressive loss of skeletal muscle mass and function during aging, is partly driven by anabolic resistance, a reduced ability of aged muscle to activate protein synthesis in response to…
Circadian aging and neurodegeneration: the emerging role of the melatonin-cortisol axis in brain homeostasis, disease progression, and precision chronomedicine.
Circadian aging may promote neurodegenerative illnesses by dysregulating the melatonin-cortisol axis.
LSD extended lifespan in tiny worms in a lab study
Researchers gave LSD to microscopic worms and found they lived longer, by up to 17.6 percent. This is a worm study, so it does not show LSD would extend human life.
Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages.
Whether a decline in taurine drives aging is debated, and despite high millimolar intracellular concentrations, its function as a potential guardian of cytosolic homeostasis is unclear.
A Cilia-Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging.
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite that regulates diverse cellular metabolic processes. Primary cilia, hair-like organelles on the cell surface, function as critical signaling hubs.
The WD40 domain of autophagy protein ATG-16.2 is required for lysosomal regulation and longevity in germline-less C. elegans
Autophagy is a conserved cellular recycling pathway linked to longevity and regulated by autophagy-related (ATG) protein.
The Lysosomal Clock: Are We Only as Old as Our Lysosomes?
Lysosomes are a major organelle involved in intracellular degradation, membrane traffic and metabolic signaling, but how their biochemical composition changes during normal aging remains poorly defined.