What this means
In this issue of Cell, Grońska-Pęski et al. examine how calorie restriction (CR) affects DNA mutation rates.
A plain-English summary is on its way. Until then, this is the start of the authors' own summary.
- Who it was tested in
- People
- Kind of research
- A study
The science
- Original title
- Calorie restriction uncouples mutation rate from lifespan.
- Authors
- Schumacher B
- Journal
- Cell
- Published
- Oct 29, 2026
- Study type
- Study · in humans
- PMID
- 42956715 ↗
Abstract
In this issue of Cell, Grońska-Pęski et al. examine how calorie restriction (CR) affects DNA mutation rates. While CR lowers the accumulation of mutations, this effect does not scale with the degree of lifespan extension. Their work raises important new questions about how CR impacts the causal mechanisms of aging.
Schumacher B Calorie restriction uncouples mutation rate from lifespan. Cell. 2026. doi:10.1016/j.cell.2026.09.038. PMID: 42956715. https://pubmed.ncbi.nlm.nih.gov/42956715/
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