Plant extracts studied for effects on aging skin cells in a preprint
Researchers tested plant extract mixes on aged skin cells and skin samples in a lab. This is an early preprint, not yet checked by other scientists, so it does not show these mixes help real skin.
Original title: Targeting skin ageing at the source: a novel cellular reprogramming approach using natural extract combinations
How aging muscle cells in blood vessels may drive heart and vessel disease
This review summarizes what scientists know about aging cells in blood vessel walls and possible drug targets. It describes ideas for future treatments, but it does not show that any treatment works in people.
Original title: Targeting Vascular Smooth Muscle Cell Senescence for Cardiovascular Pharmacology: Mechanisms and Therapeutic Perspectives.
Metformin plus exercise and diet did not improve physical function in older adults with obesity
Researchers randomly assigned older adults with obesity to lifestyle changes, with or without metformin, or diet education with metformin. Adding metformin to intensive lifestyle changes did not improve physical function beyond lifestyle changes alone.
Original title: Metformin added to lifestyle intervention for physical function in older adults with obesity (DEMFOS trial): a randomised controlled trial.
Faster changes in epigenetic clocks over time were linked to higher death risk
Researchers followed 699 adults for up to 24 years and tracked how fast their aging clocks changed. People whose clocks sped up more were more likely to die. This study shows a link, not proof that the clock changes cause death.
Original title: Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort.
Protein ZNF865 found to affect cell aging and DNA damage in spinal disc cells
Researchers found ZNF865 levels drop with age and disc disease, and changing it affected aging signs in cells. Mouse results suggest it may matter for disc damage and pain, but this does not show it works as a treatment.
Original title: ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back Pain.
Predicting compounds that may extend lifespan in worms
Researchers used gene activity patterns to predict compounds that could extend life. They tested 10 of them in tiny worms, and seven had not been reported before. This shows a possible way to find such compounds, but it does not show they work in people.
Original title: Predicting and finding geroprotective compounds through modulating conserved longevity-associated aging modules.
Semaglutide may slow some biological aging clocks in adults with HIV
In a trial of 84 adults, semaglutide was linked to slower aging scores on several blood-based measures. This was an extra analysis not planned at the start, so it cannot prove the drug slows aging.
Original title: Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy.
Low-dose rapamycin appeared safe over one year in healthy adults
A trial gave people weekly rapamycin or a placebo for 48 weeks and checked side effects and blood tests. Some measures improved in certain groups, but the researchers say more work is needed.
Original title: Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.
Why artery aging may drive heart disease beyond cholesterol
This review pulls together recent and older studies on how aging blood vessels may fuel heart disease. It does not test a treatment, and it points to ideas still being studied.
Original title: The triad of vascular ageing: Cellular senescence, inflammaging, and epigenetic remodelling in atherosclerosis.
Blood protein tests may track aging in each organ and predict disease risk
Researchers built tests that estimate organ age from proteins in blood. Older-looking organs were linked to later disease and death, but this does not show the tests change outcomes.
Original title: Organ-specific proteomic aging clocks predict disease and longevity across diverse populations.
Metformin slowed frailty and lowered biological age in older adults
In a two-year trial, metformin slowed a frailty index score and lowered two blood-based aging clocks compared with placebo. The Fried frailty score showed no lasting difference once weight loss was removed, and the results do not show that metformin prevents frailty.
Original title: A Randomized Clinical Trial of Metformin to Reduce Frailty in Older Adults with Glucose Intolerance.
Children of 100-year-olds may face later death and some diseases
Adults with a parent who lived to 100 had lower risks of death, heart disease, and high blood pressure. The study watched people over time, so it cannot prove why this happens.
Original title: Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.
Gene SRSF1 slowed signs of aging in cells and in older mice
Scientists boosted one gene in aged human cells and in mice. It made the cells and mice look younger in some ways. This does not show it would work the same way in people.
Original title: Transcriptomic reprogramming screen identifies SRSF1 as a regulator of aging.
Aging clocks linked to living to 90 in older women
Women with signs of faster aging on these tests were less likely to reach age 90. This study cannot show that the tests cause longer or shorter lives.
Original title: Epigenetic clocks of biological aging and cognitively healthy longevity: the Women's Health Initiative Memory Study.
A tea plant root extract killed aging skin cells in a lab dish
Researchers tested a tea root extract on human skin cells that had been made old in a dish. The extract killed more of the old cells than normal ones, and it also cut some inflammation signals. This does not show the extract works in people, because the tests were done in cells and skin samples.
Original title: Plant-Derived Senolytic Ingredient, Camellia sinensis Root Extract, Ameliorates Skin Aging-Associated Phenotypes.
Old, stuck cells may sometimes help cancer resist treatment
This review looks at how cells that stop dividing after cancer treatment might sometimes help tumors survive. The authors say these cells play a role only in some cases, not in every case.
Original title: Therapy-Induced Senescence in Cancer Treatment Resistance: Mechanisms, Evidence, and Translational Opportunities.
How aging liver cells affect the liver's ability to repair itself
This review looks at how aging liver cells can both help and hurt liver repair. It discusses ideas for treatments that target harmful aging cells, but it does not show that any of these treatments work in people.
Original title: Effects and Therapeutic Strategies of Intra-Hepatic Cellular Senescence and Regeneration.
How cancer treatment may age the heart and blood vessels in breast cancer patients
This review looks at how cancer treatments can leave some cells stuck in an aging state that may harm the heart. It does not prove this process causes heart damage, since other factors can also play a part.
Original title: Therapy-induced senescence in breast cancer and cardiovascular disease: a double-edged biological process.
Humanin peptide may slow aging changes in brain-like cells grown in a dish
Researchers gave a peptide called humanin to nerve cells in a lab dish. It reduced signs of cell aging and helped cells keep releasing brain chemicals. This is a lab study, so it does not show the same effect in people.
Original title: Humanin attenuates neuronal cellular senescence and preserves neurotransmitter release in differentiated PC12 cells.
How aging cell changes may relate to a type of heart failure
This review looked at studies linking aging cells and their chemical signals to a heart problem called HFpEF. The authors say most of the evidence so far comes from animal or lab work, or only shows links.
Original title: Cellular senescence in heart failure with preserved ejection fraction: Mechanisms and therapeutic opportunities.
A review proposes a link between two brain proteins and aging-related memory loss
This review looks at two brain proteins that help control inhibitory connections between nerve cells. It suggests they may work together in brain aging, but this idea is not yet proven.
Original title: The potential role of the gephyrin-CNTNAP4 interface in brain aging: Mechanisms of inhibitory circuit dysfunction and cognitive decline.
Researchers propose ways to measure how fast aging happens in mice
Scientists list 12 possible measures that may show whether a treatment slows aging in mice. These measures are not yet proven, and they still need more testing before they could be used in people.
Original title: Aging rate indicators and the search for anti-aging drugs.
A review looks at how the heart and brain may age together
This review gathers current knowledge on how the heart, blood vessels and brain age together. It proposes a framework to test this idea, but the authors say more research is needed.
Original title: Heart-brain co-ageing: phenotypic heterogeneity, molecular mechanisms and translational interventions.
How aging of the immune system may affect rheumatoid arthritis
This review explains three aging-related ideas and how they may link to rheumatoid arthritis. It says causal proof in people is still limited, and much evidence comes from animal and non-arthritis studies.
Original title: The role of immune aging in rheumatoid arthritis and its clinical and therapeutic significance.
Cell aging after cancer treatment may help or hurt tumour growth
This paper is a review of earlier research on aged cells and cancer. It says these cells may either slow or speed up tumour growth.
Original title: The Molecular Landscape of the Senescence-EMT Interplay: Deciphering Tumour Plasticity Through Molecular Signatures and Multi-Omic Profiling.
Ammonia buildup may push liver cancer cells toward death in lab tests
Researchers found that ammonia inside cancer cells can drive them to age-like senescence and then to death. They tested a drug-delivery particle that boosts this ammonia buildup in cancer cells.
Original title: The ammonia-senescence ratchet drives an adaptation-senescence-ammonioptosis transition in liver cancer
Tiny particles and microRNAs may link exercise to brain aging
This review looks at small molecules carried in body fluids that may help exercise affect the aging brain. The authors say these ideas are not yet proven and need more testing before they can be trusted as markers of brain health.
Original title: Exercise-Induced Extracellular Vesicle-Associated miRNAs in Cognitive Aging of Older Adults: A Narrative Review.
Study tests a new treatment for disc damage in cells, rats, and human disc samples
Researchers found a process linking iron buildup, damage, and aging cells in spinal discs, then built a targeted treatment. This work was done in cells and rats, so it does not show the treatment would work the same way in people.
Original title: Reprogramming NOX4-associated ferro-aging with an iron-chelating senescent-cell-targeted therapy for intervertebral disc degeneration.
Autophagy gene knockdown in worms had effects that depended on test conditions
Researchers turned down autophagy genes in tiny worms and checked how long the worms lived under different settings. The results changed with temperature, worm type, and gene, so this preprint does not clearly show how much autophagy matters for long life.
Original title: Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent
How parents' older age may affect their children's aging over time
This review pulls together earlier studies on older parents and their children's health. It suggests age-linked changes may pass to the next generation, but it is a summary, not a new test.
Original title: The intergenerational clock: How advanced parental age shapes offspring biological aging, longevity and neurodegenerative risk.