Salah Mahmoudi at ARDD2026: AlphaForge predicts clinical outcomes

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A video from ARDD, posted on Oct 26, 2026. It is about the science of aging.

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Salah Mahmoudi, SAISHO, presents at the 13th Aging Research and Drug Discovery Meeting: AlphaForge predicts clinical outcomes through multi-domain scientific reasoning Key takeaways: – Predicts clinical success and primary failure drivers from structure, target and disease alone. – Retrospective AUC 0.90 on 391 small-molecule programs; prospective AUC 0.886 on 83 programs after the model was frozen in January 2025. – Reported to outperform general LLMs by ≥29 points; identifies the primary failure reason in most cases (e.g., liver toxicity of sitaxentan). – Performance similar in trials of patients over 60. The Aging Research and Drug Discovery (ARDD) meeting is the world's leading conference dedicated to longevity biotechnology. It convenes top researchers, pharmaceutical executives, regulators, entrepreneurs, and investors to accelerate the translation of aging science into next-gene…

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