Joe Betts-LaCroix at ARDD2026: AI for rejuvenation & replacement therapies

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A video from ARDD, posted on Oct 26, 2026. It is about the science of aging.

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Joe Betts-LaCroix, Retro Biosciences, presents at the 13th Aging Research and Drug Discovery Meeting: AI for rejuvenation & replacement therapies Key takeaways: – Two strategies: replacement (young HSCs, microglia) and rejuvenation in place, aiming to add ~10 healthy years. – An autophagy-restoring small molecule is in Phase 1 in Australia, with a Phase 2 in Alzheimer’s planned for 2027. – A generative protein model produced engineered reprogramming transcription factors with improved performance; ~50% functional hit rate, with variants up to ~80% dissimilar from wild type. – Proposed that the FDA run predictive models confidentially on undisclosed trials to build trust in AI predictions. The Aging Research and Drug Discovery (ARDD) meeting is the world's leading conference dedicated to longevity biotechnology. It convenes top researchers, pharmaceutical executives, regulators, entrepr…

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