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A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M

Active not recruiting · PHASE 2 · University of Oxford

What this means

1 and R21 with Matrix-M™, in children aged 5-36 months in Burkina Faso.

A plain-English summary is on its way. Until then, this is the start of the registry's own summary.

Status
Active not recruiting
Who can join
Ages 5 Months–36 Months
Where
1 site

Contacts and how to join ↗

The science

Registered title
A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M
Phase
PHASE 2
Study type
interventional
Conditions
Malaria,Falciparum
What is tested
R21, RH5.1, R78C, Matrix-M™, Rabivax-S, Menveo, Avaxim 80
Sponsor
University of Oxford
Ages
5 Months to 36 Months
Dates
First posted Sep 19, 2025 · updated Oct 21, 2026

Registry summary

This is a Phase IIb randomised controlled trial of the safety, immunogenicity and efficacy of the malaria vaccine candidates R78C with Matrix-M™, and the combination of RH5.1 and R21 with Matrix-M™, in children aged 5-36 months in Burkina Faso.

Sites (1)

  • Institut de Recherche en Sciences de la Sante - Clinical Research Unit of Nanoro (IRSS-URCN), Nanoro, Burkina Faso

Related treatments

GlyNAC (glycine and NAC)

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