What this means
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous glucocorticoids secretion (Cushing's Syndrome during active phase, treatment and under remission and newly or on established glucocorticoid replacement therapy adrenal insufficiency)
A plain-English summary is on its way. Until then, this is the start of the registry's own summary.
- Status
- Recruiting
- Who can join
- Ages 18–80
- Where
- 1 site
The science
- Registered title
- Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
- Trial ID
- NCT04374721 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Cushing Syndrome, Adrenal Insufficiency, Cushing Disease, Addison Disease, Obesity (BMI>30)
- What is tested
- circadian gene expression evaluation
- Sponsor
- University of Roma La Sapienza
- Ages
- 18 Years to 80 Years
- Dates
- First posted May 5, 2020 · updated Oct 20, 2026
Registry summary
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous glucocorticoids secretion (Cushing's Syndrome during active phase, treatment and under remission and newly or on established glucocorticoid replacement therapy adrenal insufficiency)
Sites (1)
- Department of Experimental Medicine, "Sapienza" University of Rome, Roma, Roma, Italy