People
A premature ovarian insufficiency-associated LMD-3 point mutation impairs protein stability and causes autophagic-lysosomal dysfunction in Caenorhabditis…
Reproductive longevity decline characterizes both natural aging and premature ovarian insufficiency (POI). While our previous work established C.
People
Evaluation of surrogate biomarkers of memory and cognition in aging adults with vitamin B12 deficiency: A cross-sectional study.
BACKGROUND: Vitamin B12 (Vit B12) is a cofactor in one-carbon metabolism, methylation reactions, myelin synthesis, and neuronal function. Its deficiency can lead to neurodegeneration and cognitive decline.
Summary of earlier studies
Methylmalonic Acid in Skeletal Aging and Osteoporosis: Linking Vitamin B12 Metabolism to Mitochondrial Dysfunction.
Methylmalonic acid (MMA) is a functional marker of vitamin B12 insufficiency and an emerging metabolic factor associated with skeletal aging and osteoporosis.
Homocysteine and related B-vitamins throughout our International Conferences: a historical perspective.
In this invited keynote review, I reflect on biochemical, clinical, and epidemiological evidence on the role of folate and vitamin B12 in one-carbon metabolism and their relationship with homocysteine, integrating over…