Mixing a senescence-clearing drug with trametinib slowed glioma regrowth in mice
Researchers found a drug combination that cleared aging-like tumour cells in mice and slowed regrowth. This does not show the combination would work the same way in children.
Neuronal receptor remodeling in the aging periosteum: From single-cell atlases to regenerative targets.
The periosteum is the most densely innervated compartment of the skeleton and harbors periosteal stem cells expressing a broad repertoire of neuronal receptors traditionally associated with the nervous system.
Stem cells and exosomes studied for organ aging in animals
This is a review of 34 animal studies on stem cells and exosomes. It suggests these treatments may help aging organs, but the review does not show they work in people.
Fruit fly study finds a gene that helps remove aging gut cells
Researchers found a protein-making gene that rises in aging fruit fly gut cells and helps them get shed. This shows one possible way aging gut cells are cleared, but it is only a fruit fly finding.
Cells from a rare aging syndrome aged faster in a dish
Scientists grew skin-like cells from a patient with a rare aging syndrome and watched them age early. This is a lab study, so it does not show what happens in people.
Tiny particles from bird stem cells eased aging-like changes in gum cells in a dish
Researchers grew gum cells in a dish and exposed them to bacterial toxin. Tiny particles from bird stem cells reduced inflammation and signs of aging. This was tested only in lab cells, so it does not show what happens in people.
How aging and weight gain may work together to lower testosterone in men
This review summarizes past studies on how aging, obesity and low testosterone may feed into each other. It does not test any treatment, so it cannot show what helps men.
Quantifying punctate morphology in mesenchymal stem cells from single cell images provides a definitive quality assessment pipeline for direct correlation to…
Mesenchymal stem cells (MSCs) exhibit unique immunological properties and are classified as multipotent stem cells.
Exosome-Based Therapies for Skin Aging: Sources, Mechanisms, and Evidence from Preclinical and Clinical Studies.
Skin aging is an inevitable physiological process co-driven by endogenous genetic programs and exogenous environmental factors, characterized by the progressive deterioration of skin structure and function, which…
GDNF sustains female germline stem cell homeostasis during ovarian aging in laying hens.
Ovarian aging is a major factor contributing to the decline in egg production in laying hens, particularly during the late laying period.
Breast carcinoma amplified sequence 2 rescues adult hippocampal neurogenesis and cognitive deficits in Alzheimer's disease via regulating BDNF/TrkB signaling.
Adult hippocampal neurogenesis (AHN) occurs throughout lifespan of humans and rodents and is correlated with memory performance and cognitive plasticity.
No Female Germline Stem Cells Were Identified by Advanced Dual Recombinase-Based Lineage Tracing System.
Whether female germline stem cells (fGSCs) exist in postnatal mammalian ovaries has been debated for decades.
Gonad collagens help worms keep eggs healthy as they age
Scientists found that certain collagens in worm reproductive tissue helped keep eggs and embryos in good shape. Turning these collagens down sped up reproductive decline, but it does not show the same is true in people.
Sea cucumber tiny particles studied as possible skin aging tools
This review gathers what is known about tiny particles from sea cucumbers and their possible use in skin care. It says the ideas still need tests in people before any claims can be confirmed.
Why artery aging may drive heart disease beyond cholesterol
This review pulls together recent and older studies on how aging blood vessels may fuel heart disease. It does not test a treatment, and it points to ideas still being studied.
Gene therapy with a virus carrier for ovary aging: a review of options
This is a summary of ideas about using a harmless virus to deliver genes to the ovaries. It does not show the approach works in people.
Blocking a stem cell enzyme improved memory in aging mice
Researchers removed a lipid enzyme from brain stem cells in mice. The mice showed better brain signaling and memory tests. This was done in mice, so it does not show the same effect in people.
Blood cells turned into brain stem cells slowly lose signs of age
Blood cells from people of many ages were changed into brain stem cells in a lab. The changes in age markers kept going for weeks, so this shows a slow process.
Squeezing cell nuclei helps gene tools switch on cell changes in mice
Researchers squeezed mouse skin cells briefly, which loosened tightly packed DNA and helped gene tools work better. The skin cells from aged mice also looked biologically younger on DNA age markers.
The Oxidative-Mitochondrial-Inflammatory Axis in Retinitis Pigmentosa: Extracellular mtDNA as Biomarker and Therapeutic Read-Out.
Retinitis pigmentosa (RP) is the most common inherited retinal dystrophy (prevalence ~1:4000) and a leading Mendelian cause of working-age blindness.