Ginseng compound Rb1 eased signs of aging in the uterus in lab tests
Researchers found that Rb1 reduced aging signs in uterus lining cells and mouse uteruses. This does not show Rb1 helps aging uteruses in people.
Three common treatments and their possible links to aging and heart health
This review summarizes earlier studies on metformin, SGLT2 inhibitors, and fasting, and suggests a plan for using them together. It notes that key trials for fasting and for metformin in people without diabetes are missing.
How aging-like cell stress may affect the eye's surface
This review summarizes earlier studies on senescence, a state where cells stop dividing and release inflammatory signals. It suggests this state can help or harm the eye's surface, depending on the situation.
Hemocytes as nutrient-sensing regulators of immune function, lifespan, and intergenerational fitness in Drosophila melanogaster.
Hemocytes are the primary cellular components of the innate immune system in Drosophila melanogaster and share functional and molecular characteristics with vertebrate myeloid cells.
Pharmacological Activation of Autophagy Ameliorates Neuromuscular-Associated Defects and Extends Lifespan in a Caenorhabditis elegans Model of Spinal Muscular…
Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by homozygous deletions or mutations in the SMN1 gene, resulting in reduced levels of the ubiquitously expressed survival motor neuron protein and…
Apelin-13 protected brain cells from aging in cells and mice
Researchers found that apelin-13 helped brain cells resist aging signs by restoring their cleanup process. This work was done in cells and mice, so it does not show the same effect in people.
A prediction-interval framework for identifying outlier control cohorts in lifespan studies
Control cohorts anchor the interpretation of lifespan-extending interventions, yet their lifespans vary even under identical experimental conditions.
Harnessing autophagy and its transcriptional regulation in tumorigenesis and neurodegeneration: Potential and existing therapeutic strategies.
Autophagy is a fundamental cellular process that maintains homeostasis by degrading and recycling cellular components.
S-adenosyl-L-homocysteine triggers an adaptive response that extends lifespan through the YBT1 ABC transporter.
S-adenosyl-L-methionine (SAM) is a fundamental methyl donor; however, the physiological role of its byproduct and competitive inhibitor, S-adenosyl-L-homocysteine (SAH), remains unclear.
A review proposes a link between two brain proteins and aging-related memory loss
This review looks at two brain proteins that help control inhibitory connections between nerve cells. It suggests they may work together in brain aging, but this idea is not yet proven.
Copper and iron help yeast cells survive in different ways
Researchers studied yeast cells that were short on food. Copper and iron both helped cells survive, but through different cell signals. This is early lab work, so it does not show what happens in people.
Low-dose rapamycin appeared safe over one year in healthy adults
A trial gave people weekly rapamycin or a placebo for 48 weeks and checked side effects and blood tests. Some measures improved in certain groups, but the researchers say more work is needed.