Immune cells linked to scarring after radiation in the bowel
Researchers used computer models and mouse data to link one type of immune cell to scarring. They also suggested a peptide might target it, but this was only a computer test.
A natural peptide may protect placenta blood vessels in a pregnancy liver condition
Researchers gave a peptide called MOTS-c to mice and to human cells in a lab. It seemed to protect placenta blood vessel cells and improve some baby outcomes. This does not show the same effect in people, and more testing is needed.
Blood marker MOTS-c linked to fitness in young men
Researchers compared 30 young men who were athletes, active, or inactive. Men with higher fitness tended to have higher levels of this blood marker.
Mots-c protects kidneys in diabetic mice by lowering LARS1
Researchers found MOTS-c helped protect kidneys in mice with diabetes, and in human kidney cells. This is early work, and it does not show that MOTS-c would help people.
Peptide MOTS-c improved energy in aging egg helper cells in lab tests
Researchers gave MOTS-c to aged human helper cells and aged mouse eggs. Energy production improved and eggs matured better, though not fully to young levels.
Mitochondria-Endoplasmic Reticulum Crosstalk in Pancreatic β-Cell Stress: A Driver of Diabetes.
Pancreatic β-cell failure is central to the pathogenesis of type 2 diabetes (T2D), developing when chronic metabolic stress overwhelms the adaptive capacity of these cells.
Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility.
Female infertility affects approximately 17.5% of adults worldwide. Mitochondria are central to oocyte developmental competence, and a novel class of mitochondrial genome-encoded peptides, mitochondrial-derived…
Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.
Cardiovascular disease is strongly influenced by mitochondrial dysfunction, yet how mitochondrial stress is communicated beyond the affected cell to coordinate systemic responses remains incompletely understood.
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
Background. Chronic kidney disease [CKD] is characterized by increased glycoxidative stress, inflammation, and mitochondrial dysfunction.
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review.
BACKGROUND: Type 2 diabetes mellitus and metabolic diseases are increasing worldwide and are closely linked to mitochondrial dysfunction.
A review of MOTS-c, a small mitochondrial protein, in heart damage from sepsis
This is a review of earlier work on a small protein made by mitochondria. It finds the idea plausible but not yet well tested in sepsis-related heart damage.
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.
Myocardial infarction (MI) is characterized by severe oxidative stress, excessive inflammation, and profound mitochondrial dysfunction.
Mitochondrial peptide MOTS-c may help fight bacteria in mice and cells
Researchers found a small peptide made by mitochondrial DNA that can kill some bacteria. It was tested mostly in mice and in cells grown in a dish, so it does not show what happens in people.
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality and limited effective pharmacotherapies.
Emerging regulators of human physiology and disease; sORF-encoded microproteins.
The human genome contains hundreds of thousands of short open reading frames (sORFs), yet their translational products, hereafter referred to as sORF-encoded microproteins (also historically termed micropeptides), have…