How people get it: Not approved for use in people. Tested in mice; no trials in people.
FDA status, evidence and safety
Not FDA-approvedNot approved; studied in labs
- FDA status
- Not FDA-approved, and not on the FDA's lists of substances nominated for pharmacy compounding. FDA compounding list ↗FDA safety-risk list ↗
- In people so far
- In fast-aging and naturally old mice, FOXO4-DRI restored fitness, fur density and kidney function. PubMed ↗
- Safety
- No trial in people is listed on ClinicalTrials.gov. ClinicalTrials.gov ↗
- In sport
- Not named on the World Anti-Doping Agency's 2026 Prohibited List. WADA ↗
One of the peptides we follow. We don't give doses or say where to buy. Talk to your doctor before trying any of them.
The basics
We're still gathering this from reference sources like the NIH and MedlinePlus. Sections appear here once every sentence is checked against its source.
What it is
Not enough reliable information yet.
How it's thought to work
Not enough reliable information yet.
What people use it for
Not enough reliable information yet.
What the research has found so far
On FOXO4-DRI and aging, PubMed lists 0 trials in people, 0 studies that watched people over time, 5 animal and lab studies. See the counts and searches
Stage 1 because no trials in people were found yet.
A stage shows how far research has got, not whether it will work for you. How stages work
Side effects and risks
Not enough reliable information yet.
Who should be careful, and drug interactions
Not enough reliable information yet.
What to expect
Not enough reliable information yet.
Amounts used in studies
What studies or labels describe, not a recommendation.
Not enough reliable information yet.
Roughly what it costs
We don't have prices for this yet.
Questions to ask your doctor
- Is FOXO4-DRI a sensible option for me, given my health and the medicines I take?
- Could FOXO4-DRI interact with any medicine or supplement I already take?
- What side effects should I watch for, and when should I stop or call you?
- How would we tell whether it is helping, and when should we review it?
This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.
What experts say
No expert views collected yet. Each one we add names the person and links to where they said it.
Recent research
New studies that mention FOXO4-DRI appear here after the morning update.
Trials
None of the registered trials of FOXO4-DRI is one we have linked as aging-related yet.
The science
Counted from PubMed and ClinicalTrials.gov on Oct 30, 2026, using one search for FOXO4-DRI in relation to aging. Each link opens the exact search.
- Randomized trials in people
- 0 search ↗
- Large trials (multicenter or phase 3)
- 0 search ↗
- Phase 3 trials
- 0 search ↗
- Trials in people
- 0 search ↗
- Studies that watched people over time
- 0 search ↗
- Animal and lab studies
- 5 search ↗
- Registered trials
- 0 search ↗
PubMed search used
("FOXO4-DRI"[tiab] OR "FOXO4 DRI"[tiab] OR proxofim[tiab])
Counts are search results, so they include some records that only mention FOXO4-DRI. How we count
Cite or share this page
Longevity Progress. (n.d.). FOXO4-DRI: Research stage and evidence. Retrieved October 30, 2026, from https://longevityprogress.com/treatments/foxo4-dri
<iframe src="https://longevityprogress.com/embed/stage/foxo4-dri" title="FOXO4-DRI: research stage on Longevity Progress" width="340" height="72" style="border:0" loading="lazy"></iframe>
The badge shows this treatment's current research stage and links back here. It updates by itself when the stage changes.