What this means
Maternal age is the primary risk factor for aneuploidy in mammalian oocytes, but the molecular mechanisms that preserve meiotic chromosome segregation fidelity during aging remain incompletely understood. Using ultrastructural analysis, we observe that spindle microtubules in aged mouse oocytes tend to exhibit increased misorientation and shorter interaction lengths, whereas microtubule number and density remain largely unchanged.
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- Who it was tested in
- Animals or cells
- Kind of research
- Research in animals or cells
The science
- Original title
- Declining centromere strength compromises meiotic chromosome segregation in aging oocytes.
- Authors
- Lemonnier T, Dumont M, Leem J et al.
- Journal
- The Journal of cell biology
- Published
- Oct 19, 2026
- Study type
- Lab or animal study · indexed as animal research
- PMID
- 42895520 ↗
Abstract
Maternal age is the primary risk factor for aneuploidy in mammalian oocytes, but the molecular mechanisms that preserve meiotic chromosome segregation fidelity during aging remain incompletely understood. Using ultrastructural analysis, we observe that spindle microtubules in aged mouse oocytes tend to exhibit increased misorientation and shorter interaction lengths, whereas microtubule number and density remain largely unchanged. We demonstrate that the levels of the key centromeric components CENP-A and CENP-C are reduced in oocytes from aged mice. Acute degradation of CENP-A during meiosis I affects CENP-C stability at centromeres and causes chromosome segregation errors in young oocytes, a phenotype not observed in mitosis. The expression of exogenous CENP-C rescues these defects via CENP-B-dependent centromere binding, supporting a link between centromere weakening and meiotic errors. This intervention also partially improves chromosome alignment in oocytes from older animals. Together, these findings implicate centromere weakening, alongside cytoskeletal disorganization, in the age-related decline in chromosome segregation fidelity in oocytes.
Lemonnier T, Dumont M, Leem J et al. Declining centromere strength compromises meiotic chromosome segregation in aging oocytes. The Journal of cell biology. 2026. doi:10.1083/jcb.202606132. PMID: 42895520. https://pubmed.ncbi.nlm.nih.gov/42895520/