What this means
Insulin/IGF signaling (IIS) inhibits the nuclear localization of the DAF-16 /FOXO transcription factor to regulate longevity and stress resistance in C. elegans .
A plain-English summary is on its way. Until then, this is the start of the authors' own summary.
- Who it was tested in
- Not stated
- Kind of research
- A study
The science
- Original title
- TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the C. elegans intestine.
- Authors
- Saha S, Meras I, Rocheleau CE
- Journal
- microPublication biology
- Published
- Oct 29, 2026
- Study type
- Study
- PMID
- 42953546 ↗
Abstract
Insulin/IGF signaling (IIS) inhibits the nuclear localization of the DAF-16 /FOXO transcription factor to regulate longevity and stress resistance in C. elegans . In the intestine, IIS promotes DAF-16 localization to endosomes and loss of TBC-2 , a RAB-5 GAP, results in increased endomembrane localization of DAF-16 at the expense of nuclear localization, decreased DAF-16 target gene expression, longevity and stress resistance. Here we found that TBC-2 differentially regulates the localization of the IIS-regulated transcription factors PQM-1 and HLH-30 /TFEB. Our results suggest a broader role for TBC-2 in regulating IIS and that TBC-2 likely functions at an upstream point in the IIS pathway.
Saha S, Meras I, Rocheleau CE TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the C. elegans intestine. microPublication biology. 2026. doi:10.17912/micropub.biology.002470. PMID: 42953546. https://pubmed.ncbi.nlm.nih.gov/42953546/