What this means
Chronic low-grade inflammation ("inflammaging") drives age-related decline, but whether anti-inflammatory medications preserve functional performance in older age remains unknown. This study evaluated the 5-year effect of aspirin on a modified Intrinsic Capacity (IC) index in older males and females.
A plain-English summary is on its way. Until then, this is the start of the authors' own summary.
- Who it was tested in
- Not stated
- Kind of research
- A study
The science
- Original title
- Validation of an intrinsic capacity index and the effects of aspirin in older males and females: secondary analysis of a randomized controlled trial.
- Authors
- Ryan J, Phyo AZZ, Wieczorek M et al.
- Journal
- GeroScience
- Published
- Oct 29, 2026
- Study type
- Study
- PMID
- 42955660 ↗
Abstract
Chronic low-grade inflammation ("inflammaging") drives age-related decline, but whether anti-inflammatory medications preserve functional performance in older age remains unknown. This study evaluated the 5-year effect of aspirin on a modified Intrinsic Capacity (IC) index in older males and females. A post-hoc analysis of a randomised controlled trial comparing daily 100 mg aspirin to placebo in prolonging dementia- and disability-free survival (DFS) in community-dwelling individuals aged ≥ 65 years. A four-domain IC score (including cognition, locomotion, vitality and psychological well-being) was calculated annually across 18,581 participants and validated against biological and clinical measures. Linear mixed models compared IC trajectories across treatment arms. Females had lower baseline IC and a steeper decline over time than males. IC correlated with chronological age (r = - 0.30, both sexes), a system-wide deficit-accumulation index (r = - 0.56 and - 0.54 in females and males respectively), and epigenetic clocks (e.g., PC-PhenoAge, PC-GrimAge, and DunedinPACE), particularly in females. Clinically, lower baseline IC was associated with reduced DFS in both sexes (Q1 vs. Q5: HR = 4.62, 95% CI: 3.16-6.75; HR = 4.32, 95% CI: 3.42-5.48). Females randomized to aspirin had a small but significantly accelerated decline in IC (β: - 0.006, 95% CI: - 0.01, - 0.001, p = 0.01), whereas no effect was observed in males (p = 0.86; 3-way sex*treatment*time p = 0.06). Low-dose aspirin did not prevent functional decline and unexpectedly was associated with a small additional decline in IC in older females, highlighting the need to consider sex-specific responses to therapies.
Ryan J, Phyo AZZ, Wieczorek M et al. Validation of an intrinsic capacity index and the effects of aspirin in older males and females: secondary analysis of a randomized controlled trial. GeroScience. 2026. doi:10.1007/s11357-026-02624-x. PMID: 42955660. https://pubmed.ncbi.nlm.nih.gov/42955660/