What this means
Researchers found that injured mouse gut and liver cells looked younger by their gene patterns during repair. This is a preprint, so other scientists have not checked it yet.
Plain-English summary written by an AI model from the abstract. The original is below.
- Who it was tested in
- Mice
- Kind of research
- Early results, not yet checked by other scientists
The science
- Original title
- Transcriptomic rejuvenation during intestinal and liver regeneration in mice
- Authors
- Iqbal, S., Gladyshev, V. N.
- Journal
- bioRxiv (preprint, not yet peer reviewed)
- Published
- Oct 13, 2026
- Study type
- Preprint
Abstract
Aging and regeneration are fundamental biological processes, but the relationship between them is poorly understood. During intestinal regeneration, adult epithelial cells reactivate developmental programs that support repair. To investigate if this plasticity alters tissue biological age, we developed and validated intestinal tissue and epithelium-specific transcriptomic aging clocks. Across various regeneration models, epithelial states were predicted by these clocks to be younger than controls. Their expression changes were also negatively associated with intestinal stem-cell and progenitor aging signatures. The resulting younger state was characterized by YAP-associated regeneration and reduced mature enterocyte identity. In a separate irradiation model, the predicted epithelial age first increased, then fell at the peak of regeneration and later increased again during recovery. In a chemotherapy-induced injury model, epithelium in both young and old animals also reversibly transitioned through this younger state, returning to its preinjury state during recovery, although regenerative and fetal-like gene expression differed with host age. Further spatial transcriptomic analyses linked lower epithelial age with regeneration in selected injured and tumor-associated regions. In addition, liver regeneration after partial hepatectomy in old animals was also accompanied by decreased transcriptomic age, which persisted to the last sampled time point, and by pathway changes negatively associated with aging signatures. Overall, these findings suggest that mammalian regeneration is associated with a transient reduction in transcriptomic age, whose timing and persistence depend on tissue and the course of repair.
Iqbal, S., Gladyshev, V. N. Transcriptomic rejuvenation during intestinal and liver regeneration in mice. bioRxiv. 2026. doi:10.64898/2026.10.11.758291. https://doi.org/10.64898/2026.10.11.758291