What this means
Birds provide a unique model for ageing research, with greater longevity and slower senescence compared to mammals of similar size, despite a higher mass-adjusted metabolic rate and blood glucose levels than other vertebrate groups. While the effects of glucose, glycation, and advanced glycation end-products (AGEs) on ageing are well-documented in biomedical research, their impact on avian physiology and ageing remains poorly understood.
A plain-English summary is on its way. Until then, this is the start of the authors' own summary.
- Who it was tested in
- Not stated
- Kind of research
- Early results, not yet checked by other scientists
The science
- Original title
- Decoupling glycation from mortality: glucose, but not methylglyoxal, reduces survival in zebra finches
- Authors
- Moreno Borrallo, A., Jaramillo Ortiz, S., Schaeffer-Reiss, C. et al.
- Journal
- bioRxiv (preprint, not yet peer reviewed)
- Published
- Oct 21, 2026
- Study type
- Preprint
Abstract
Birds provide a unique model for ageing research, with greater longevity and slower senescence compared to mammals of similar size, despite a higher mass-adjusted metabolic rate and blood glucose levels than other vertebrate groups. While the effects of glucose, glycation, and advanced glycation end-products (AGEs) on ageing are well-documented in biomedical research, their impact on avian physiology and ageing remains poorly understood. Although birds may possess adaptations mitigating the potential detrimental effects of glucose, elevated glucose still predicts reduced lifespan, and protein glycation varies with age and can influence fitness-related traits, implying that glycation or AGEs accumulation may have relevant effects on avian longevity. In this study, we experimentally investigated how one year of dietary supplementation with glucose or methylglyoxal affects survival and physiology (metabolic rate, flying performance, and beak coloration) in captive zebra finches (Taeniopygia guttata). We reveal a significant increase in mortality and an elevated albumin glycation rate in glucose-supplemented birds. AGEs increased in both supplemented groups, but this and glycation did not help explain the increased mortality in glucose-supplemented birds. Additionally, we observed an age-related constraint on seasonal metabolic adjustment and an age-related decline in beak coloration. This secondary sexual trait was affected by both supplementation treatments. Furthermore, flight performance was lower in supplemented birds, particularly in the glucose group, during the peak mortality period, suggesting a broader deterioration in health. Thus, although glucose supplementation was more deleterious than methylglyoxal, the underlying mechanisms responsible for the increase in mortality remain to be elucidated in future studies.
Moreno Borrallo, A., Jaramillo Ortiz, S., Schaeffer-Reiss, C. et al. Decoupling glycation from mortality: glucose, but not methylglyoxal, reduces survival in zebra finches. bioRxiv. 2026. doi:10.64898/2026.05.04.722681. https://doi.org/10.64898/2026.05.04.722681